Comparative evaluation of different doses of gabapentin and celecoxib as multimodal oral analgesia in patients of spine fixation surgery | ||
| Minia Journal of Medical Research | ||
| Article 19, Volume 30, Issue 4, October 2019, Pages 113-120 PDF (486.33 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjmr.2022.221697 | ||
| Authors | ||
| Amna Th. Gadelrab Radwan; Khaled A. Abdou; Al Shimaa I. Roushdy | ||
| Department of Anesthesia, El-Minia Faculty of Medicine | ||
| Abstract | ||
| Introduction: Since an increased number of major spinal procedures, including revision surgery can be anticipated, we found it of relevance to assess a multimodal pain treatment strategy in patients undergoing surgery requiring instrumentation. Aim of the work: The aim of this randomized doubleblinded study to asses and compare the efficacy of using different doses of gabapentin and celecoxib as combination for analgesia in postoperative pain relieve in patient underwent posterior approach lumbar spine fixation surgery. Patients and Methods: After obtaining the local ethics committee of Minia University Hospital approval and written informed consent was taken from the patient, one hundred patients of both gender, Patients were randomized to four groups (25 patients in each group): Group GC received gabapentin 300mg + celecoxib 200mg 2hr preoperative and the same combination 6 hr postoperative. Group G received gabapentin 300mg + celecoxib 200mg 2hr preoperative and gabapentin 300mg 6 hr postoperative. Group C received gabapentin 300mg + celecoxib 200mg at both 2hr preoperative and celecoxib 200mg 6 hr postoperative. Group O (placebo) as a control group received empty capsules 2hr preoperative and 6 hr postoperative VAS score obtained from all patients immediately after recovery from anesthesia, at 2hr, 4hr, 6hr, 8hr, 10hr, 12hr, and 24hr post-operative. Results: Postoperative VAS score was significantly lower in the three groups (GC, G, and C) respectively when compared with group O. Discussion: Spinal procedures are associated with high level of postoperative pain compared to other surgical procedures and the majority of patients report moderate to severe pain, which persists for at least initial 3-4 days. Recommendation: Based on the the current study we recommend: Usage of primitive multimodal analgesic with the various mechanism of action is more useful in post-operative pain relieve after major surgery. | ||
| Keywords | ||
| Acute neuropathic pain; Hour; Minimal invasive spine surgery; Noninvasive blood pressure | ||
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