Sholkamy, N., Abd El-Latif, W., Hassan, M., Guirguis, A., Kamal, M. (2019). Change of estrogen receptor, progesterone receptor, and Ki67 after neoadjuvant chemotherapy in patients with locally advanced breast cancer. test, 30(4), 217-225. doi: 10.21608/mjmr.2022.221719
Nada H. Ali Sholkamy; Wafaa M. Abd El-Latif; Mohamed A. Hassan; Amani S. Guirguis; Marian F. Kamal. "Change of estrogen receptor, progesterone receptor, and Ki67 after neoadjuvant chemotherapy in patients with locally advanced breast cancer". test, 30, 4, 2019, 217-225. doi: 10.21608/mjmr.2022.221719
Sholkamy, N., Abd El-Latif, W., Hassan, M., Guirguis, A., Kamal, M. (2019). 'Change of estrogen receptor, progesterone receptor, and Ki67 after neoadjuvant chemotherapy in patients with locally advanced breast cancer', test, 30(4), pp. 217-225. doi: 10.21608/mjmr.2022.221719
Sholkamy, N., Abd El-Latif, W., Hassan, M., Guirguis, A., Kamal, M. Change of estrogen receptor, progesterone receptor, and Ki67 after neoadjuvant chemotherapy in patients with locally advanced breast cancer. test, 2019; 30(4): 217-225. doi: 10.21608/mjmr.2022.221719

Change of estrogen receptor, progesterone receptor, and Ki67 after neoadjuvant chemotherapy in patients with locally advanced breast cancer

Minia Journal of Medical Research
Article 35, Volume 30, Issue 4, October 2019, Pages 217-225    PDF (394.87 K)
Document Type: Original Article
DOI: 10.21608/mjmr.2022.221719
Authors
Nada H. Ali Sholkamy1; Wafaa M. Abd El-Latif2; Mohamed A. Hassan3; Amani S. Guirguis2; Marian F. Kamal4
1Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicin, Minia University
2Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicin, Minia University.
3Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicin, Cairo University.
4Department of Pathology, Faculty of Medicin , Minia University
Abstract
Purpose: The aim of this study is aimed to demonstrate the changes in the estrogen receptor 
(ER), progesterone receptor (PR), Ki-67, after neoadjuvant chemotherapy in the patients with 
locally advanced breast cancer. Materials and Methods: seventy patients who diagnosed 
with locally advanced breast cancer and treated with neoadjuvant chemotherapy. Ki-67, ER, 
PR, tested by immunohistochemistry (IHC) was evaluated before and after neoadjuvant 
chemotherapy. Results: There was a statistically significant reduction in Ki-67, but no 
statistically significant reduction in ER, PR, after neoadjuvant chemotherapy. Conclusion: 
The significant change in the Ki-67 proliferation index may suggest the reduced proliferative 
activity of malignant cells with neoadjuvant chemotherapy.

Keywords
estrogen receptor; progesterone receptor; neoadjuvant chemotherapy
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