Kamel, S., Mohammed, R., Moens, H., Ibrahim, R. (2019). Frequency of neuropathic pain and its impact on functional status in primary knee osteoarthritis patients. test, 30(3), 12-18. doi: 10.21608/mjmr.2022.221847
Shereen R. Kamel; Rania M. Mohammed; Hend M. Moens; Radwa S. Ibrahim. "Frequency of neuropathic pain and its impact on functional status in primary knee osteoarthritis patients". test, 30, 3, 2019, 12-18. doi: 10.21608/mjmr.2022.221847
Kamel, S., Mohammed, R., Moens, H., Ibrahim, R. (2019). 'Frequency of neuropathic pain and its impact on functional status in primary knee osteoarthritis patients', test, 30(3), pp. 12-18. doi: 10.21608/mjmr.2022.221847
Kamel, S., Mohammed, R., Moens, H., Ibrahim, R. Frequency of neuropathic pain and its impact on functional status in primary knee osteoarthritis patients. test, 2019; 30(3): 12-18. doi: 10.21608/mjmr.2022.221847

Frequency of neuropathic pain and its impact on functional status in primary knee osteoarthritis patients

Minia Journal of Medical Research
Article 3, Volume 30, Issue 3, July 2019, Pages 12-18    PDF (411.67 K)
Document Type: Original Article
DOI: 10.21608/mjmr.2022.221847
Authors
Shereen R. Kamel1; Rania M. Mohammed1; Hend M. Moens2; Radwa S. Ibrahim1
1Department of Rheumatology and Rehabilitation,
2Department of Clinical Pathology, Faculty of Medicine, El-Minia University, Egypt
Abstract
Background: Neuropathic mechanisms are considered to play a role in development of pain in knee 
osteoarthritis (OA). Some OA patients developed sensitized central nociceptive circuits that enhance pain 
during various states of peripheral tissue insult. Method: 70 patients with primary knee OA were enrolled 
in this study. Antero-posterior knee radiographs were done using the Kellgren Lawrence scale. Pain 
severity was assessed by Numerical rating scale (NRS), neuropathic pain was assessed by Douleur 
Neuropathique en 4 (DN4) questionnaire and functional status was assessed by the Western Ontario and 
McMaster Universities Osteoarthritis Index (WOMAC) scale. Results: 52.9% of the patients had 
neuropathic pain according to DN4 scale. The mean pain WOMAC score and WOMAC physical 
function score were significantly higher in patients with neuropathic pain when compared to patients with 
non-neuropathic pain; 9.86 ± 2.1 versus 6.79 ± 3.59, P <0.0001 and 44.24 ± 5.43 versus 39.39 ± 10.36, P
= 0.015 respectively. DN4 score had a significant positive correlation with WOMAC pain (r=0.459,
P<0.001), stiffness (r=0.258, P=0.031) and physical function (r=0.307, P=0.01). Conclusion: Chronic
pain with OA has neuropathic components. Neuropathic pain is a factor that increases pain and disability 
and disrupts functional status in osteoarthritis patients.

Keywords
Osteoarthritis; Neuropathic pain; Douleur Neuropathique en 4 Questions
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