Efficacy of sublingual immunotherapy in adult allergic asthma from Minia University hospitals | ||
| Minia Journal of Medical Research | ||
| Article 30, Volume 30, Issue 3, July 2019, Pages 146-149 PDF (380.46 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjmr.2022.221916 | ||
| Authors | ||
| Hala A. Mohammed1; Rasha Y. Shahin2; Ahmed H. kasem1; Haitham E. Refaat1 | ||
| 1Department of chest diseases, Faculty of medicine, Minia university, Egypt | ||
| 2Department of allergy and clinical immunology, Faculty of medicine, Ain shames university, Egypt | ||
| Abstract | ||
| Background: specific immunotherapy is the sole treatment for changing the natural course of allergic diseases and minimizing the risk of an exacerbation. Sublingual immunotherapy is may be preferred worldwide considering the favorable safety profile and absence of anxiety provoking injections. Many updated recommendations of its use with reports emphasize the need for a methodological control of research projects in order to increase their objectivity. Patients and methods: this study is designed to be open labeled, randomized and double armed parallel groups; 80 adult asthmatic patients were screened for mild to moderate persistent asthma by history, clinical examination ,chest X ray ,FEV1 , then screened for atopic sensitized patients with total IgE and skin prick test . Then patients were randomized into 2 equal groups, group 1 received ICS plus SLIT for 9 months and group 2 received ICS for the same period. Serum total IgE was evaluated before and after treatment, every 3 months FEV1 was evaluated and monthly clinical evaluation by Asthma symptom control sheet, medication score were done throughout the entire period. Results: 80 patients were randomized into 2 equal groups, group 1 received ICS plus SLIT for 9 months and group 2 received ICS for the same period. In group 1 serum level of total IgE after treatment show a significant decrease while FEV1 after treatment show significant increase. In group 2 serum level of total IgE after treatment show no significant difference while FEV1 show no significant difference. Conclusion: Serum level total IgE is a good biomarker significantly decreased with SLIT therapy. | ||
| Keywords | ||
| SLIT; allergen immunotherapy; allergic diseases; atopic; asthma; asthma control; asthma exacerbations; lung function | ||
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