Impact of Vitamin D Supplementation in Acute and Chronic Immune Thrombocytopenia in Children. | ||
| Minia Journal of Medical Research | ||
| Article 35, Volume 30, Issue 3, July 2019, Pages 173-176 PDF (418.81 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjmr.2022.221922 | ||
| Authors | ||
| Mostafa A. Elfouly1; Sheren E. Maher1; Waleed M. Abd El Hameed2; Ibrahim Y. Shihata1 | ||
| 1Department of Pediatrics, El-Minia Faculty of Medicine | ||
| 2Department of Clinical Pathology, El-Minia Faculty of Medicine | ||
| Abstract | ||
| Introduction: Immune thrombocytopenia (ITP) is the commonest cause of pediatric thrombocytopenia. Vitamin D (VD) is multifunctional hormone that regulates multiple activities in human body especially in immune system. Aim of the work: to investigate the role of VD as an immune modulating drug in the treatment of ITP in children. Patients and Methods: This cohort study was carried out on 80 patients with ITP. Cases are taken and divided into: Group I: It includes 40 children with acute ITP. They were subdivided into: Group I.A: 20 children will receive VD supplementation & Group I.B: 20 children will not receive VD. Group II: It includes 40 children with chronic ITP. They were subdivided into: Group II.A: 20 children will receive VD supplementation & Group II.B: 20 children will not receive VD. Results: VD level was low in all cases. VD supplementation improved platelets count. Discussion: VD deficiency may contribute to pathogenesis of ITP. VD supplementation was beneficial for acute and chronic ITP in children. Recommendation: Based on the current study we recommend VD assay in all cases of ITP to detect deficiency and give supplementation. | ||
| Keywords | ||
| ITP: Immune thrombocytopenia; VD: Vitamin D | ||
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