Detection of the level of micro RNA 224 in patients with hepatocellular carcinoma. | ||
| Minia Journal of Medical Research | ||
| Article 51, Volume 30, Issue 3, July 2019, Pages 242-245 PDF (164.85 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjmr.2022.221954 | ||
| Authors | ||
| Nady M. Semeda; Hala I. Mohammed; Zeinab M. Saad; Wael Soliman | ||
| Department of Tropical Medicine, Faculty of Medicine, Minia University. | ||
| Abstract | ||
| Background: Liver cancer, predominantly hepatocellular carcinoma (HCC), is the second most deadly cancer worldwide. HCC is the most rapidly increasing cause of cancer-related mortality in the U.S. In Canada, total health care costs associated with HCV are expected to increase by 60% until they peak in 2032. Given the extremely frequent tumour recurrence even after aggressive treatment (70% after 5 years of surgical resection) and limited treatment options available for advanced-stage liver disease, including liver transplantation, a costly proposition, prevention of HCC development in patients with advanced liver fibrosis may be the most effective strategy to substantially impact patient survival. Aim of study: to detect the level of miR224 in different stages of hepatocellular carcinoma. Methods: An observational study, in Tropical Medicine Department, El-Minia University Hospital, ElMinia,-Egypt. Patients with hepatocellular carcinoma on top of HCV induced Liver cirrhosis collected among the patients of tropical medicine department from January 2017 to January 2018. Patients were divided into 3 groups according to Barcelona classification of liver cancer (BCLC) into, group 1 with BCLC A, group 2 with BCLC B, group C with BCLC C, and control group of LC without HCC, for all groups: history, examination and routine investigations, abdominal ultrasound, Multislice CT scan and miR-224 assay were done. Results: there was a significant difference between the level of miR 224 in different stages of hepatocellular carcinoma with the lowest level in BCLC A and the highest level in BCLC C with P value 0.001 indicating its role in predicting aggressiveness of hepatocellular carcinoma. Conclusion: miR-224 could serve as a good prognostic biomarker for HCC, and can be used as a marker predicting aggressiveness of HCC. | ||
| Keywords | ||
| LC; Hepatocellular carcinoma; miR–224 | ||
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