Structural and Ultrastructural Examination of Anti-Arthritic Effect of Bee Venom in Temporomandibular Joint with Induced Rheumatoid Arthritis in Albino Rats | ||
| Dental Science Updates | ||
| Article 7, Volume 3, Issue 1, March 2022, Pages 45-55 PDF (2.57 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/dsu.2022.93870.1079 | ||
| Authors | ||
| Marwa El shafie* 1; Enas Hegazy2; Mervat Youssef3 | ||
| 1Assistant lecturer of Oral biology department, Faculty of Dentistry, Suez Canal University, Ismaillia, Egypt. | ||
| 2Associate Professor of Oral Biology department, Faculty of Dentistry, Suez Canal University, Ismailia, Egypt. | ||
| 3Associate Professor of Oral Biology department, Faculty of Dentistry, Suez Canal University, Sphinx University, Egypt. | ||
| Abstract | ||
| Introduction: Bee venom is broadly utilized in conventional Chinese medication for the treatment of fiery maladies, such as rheumatoid arthritis and to lighten the related pain. Aim: This research aimed to investigate the anti-arthritic impact of bee venom in repairing the possible structural and ultrastructural changes in the temporomandibular joint of albino rats with induce rheumatoid arthritis. Material and Methods: Thirty adult male albino rats were used in this investigation. The animals were divided into; Group 1: (n=10) served as negative control; Group 2: (n=20) they received 7 intraarticular injections of 0.02 ml of carrageenan solution in order to induce Rheumatoid Arthritis. Then after, the animals of group 2 were divided equally into; Subgroup 2.1: served as positive controls; Subgroup 2.2: were treated by subcutaneous injection of 0.2ml of bee venom solution for 12 weeks. At the end of the experiment the rats of different groups were euthanized then the head of each animal was divided sagittally into two halves; the right halves of all groups were used for structural examination while the left halves were used for ultrastructural examination. Results: Biochemical results revealed subgroup 2.2 showed a significant decrease in the values compared with subgroup < br />2.1. Histological and electron microscopic examination of the present sections of subgroup 2.1 showed variable microscopically degenerative changes compared to control group 1; while the present sections of subgroups 2.2 revealed marked improvement of the different components of rat’s temporomandibular joint. Conclusion: Bee venom have antiarthritic effect in arthritic rat’s temporomandibular joint. | ||
| Keywords | ||
| Anti-arthritis; Bee venom; Carrageenan; Inflammation; Rheumatoid arthritis; Temporomandibular joint | ||
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