Histological study of the protective effect of Selenium against Nephrotoxicity induced by Aspartame in adult male albino rats | ||
| Minia Journal of Medical Research | ||
| Volume 30, Issue 1, March 2019, Pages 1-12 PDF (841.55 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjmr.2022.222761 | ||
| Authors | ||
| Mohammed A. Desouky; Medhat A. Salah; Abdel Hamid S. Abo Bakr; Heba H. Sedki Tony | ||
| Department of Anatomy and Embryology, Faculty of Medicine, Minia University | ||
| Abstract | ||
| The objective of the present study is to explore the protective effect of selenium against nephrotoxicity induced by aspartame in adult male albino rat. Forty-five adult male albino rats, weighting 180 were randomly divided into three groups as follows: first group was given distilled water and served as control group; the second group was given aspartame dissolved in distilled water in a dose of 500 mg /kg b. wt.; the third group was given both aspartame and selenium. Selenium was given at daily dose 0.2 mg/kg dissolved in distilled water and given intra peritoneal followed by aspartame with an hour interval for 6 weeks. Serum urea, creatinine were significantly increased in rats that had received aspartame also the body was significantly decreased in rats received aspartame. Combined Treatment with selenium significantly restored kidney functions, modulate weight parameters. | ||
| Keywords | ||
| selenium; nephrotoxicity; aspartame; Serum urea; creatinine | ||
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