Afifi, M., Aboul-Fotoh, L., Ahmed, M., Hassan, M. (2019). Serum Dickkopf-1 level in neonates with Hypoxic-Ischemic Encephalopathy. test, 30(1), 62-65. doi: 10.21608/mjmr.2022.222769
Mohamed F. Afifi; Laila E. Aboul-Fotoh; Mostafa A. El-Sayed Ahmed; Mona M. Hassan. "Serum Dickkopf-1 level in neonates with Hypoxic-Ischemic Encephalopathy". test, 30, 1, 2019, 62-65. doi: 10.21608/mjmr.2022.222769
Afifi, M., Aboul-Fotoh, L., Ahmed, M., Hassan, M. (2019). 'Serum Dickkopf-1 level in neonates with Hypoxic-Ischemic Encephalopathy', test, 30(1), pp. 62-65. doi: 10.21608/mjmr.2022.222769
Afifi, M., Aboul-Fotoh, L., Ahmed, M., Hassan, M. Serum Dickkopf-1 level in neonates with Hypoxic-Ischemic Encephalopathy. test, 2019; 30(1): 62-65. doi: 10.21608/mjmr.2022.222769

Serum Dickkopf-1 level in neonates with Hypoxic-Ischemic Encephalopathy

Minia Journal of Medical Research
Volume 30, Issue 1, March 2019, Pages 62-65    PDF (232.37 K)
Document Type: Original Article
DOI: 10.21608/mjmr.2022.222769
Authors
Mohamed F. Afifi1; Laila E. Aboul-Fotoh1; Mostafa A. El-Sayed Ahmed2; Mona M. Hassan3
1Department of Pediatrics, Minia University, Minia, Egypt
2Department of Clinical Pathology, Minia University, Minia, Egypt
3Department of Clinical Pathology, Minia health insurance hospital, Minia, Egypt
Abstract
Objective: To measure the serum Dickkopf-1 level in neonates with HIE and to study its 
relation to the neurodevelopmental outcome in those neonates in comparison to healthy neonates. 
Methods: We measured serum levels of Dkk-1 by ELISA in neonates with HIE (n = 40) and in 
healthy controls (n = 30). Results: Dkk-1 serum levels increased significantly in HIE neonates than in 
healthy control, Serum DKK-1 levels increased significantly in severe HIE patients. Conclusion: 
DKK1 level was higher in neonates with HIE than normal neonates and DKK1 level correlated 
positively with the degree of HIE.

Keywords
Dickkopf-1; neonates; Hypoxic-Ischemic
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