A Comparative Study between Total and modified Subtotal Thyroidectomy for the Management of Graves' Disease | ||
| Minia Journal of Medical Research | ||
| Volume 30, Issue 1, March 2019, Pages 108-113 PDF (164.3 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjmr.2022.222806 | ||
| Authors | ||
| Adel M. Khalaf; Abd Elkarim E. Abd Elkarim; Ahmed F. Mehanny | ||
| Department of General Surgery, Faculty of Medicine Al-Azhar University – Assuit | ||
| Abstract | ||
| Background: Grave’s disease is an autoimmune disease caused by thyroid receptor antibodies that activate the thyrotrophin receptor, leading to stimulation of cyclic adenosine monophosphate synthesis and production of thyroid hormones in the follicular cells. The prevelance of GD is 0.5% of the population and is the underlying aetiology for 50-80% of cases of hyperthyroidism. Objective: To compare total vs modified subtotal thyroidectomy in the management of Graves' disease as regards control of the disease, incidence of recurrence and postoperative complications. Patients and Methods: Our study was conducted on 40 patients suffering from GD that had been recruited from the out-patient clinic of surgical department of Al-Azhar Assuit University Hospital. 20 cases have total thyroidectomy and the other 20 have had modified subtotal thyroidectomy. Inclusion criteria was the age from 20 to 60 years (males or females) and failed medical treatment for 6 months. Patients excluded were those less than 20 years old, exophthalmous, chronic debilitating disease, malignancy, and any patient with preoperative vocal cord affection. Results: The range of pre-operative thyroid profile shows T3 level 9.4+/-2, T4 level 6.1+/-2 while TSH level 0.08+/-0.02 in total thyroidectomy group and T3 level 8.9+/-2, T4 level 5.5+/-21.6 while TSH level 0.09+/-0.01in modified subtotal group. This study showed no significant changes in both groups as regards postoperative hospital stay. In our study showed that hyocalcemia is the most common immediate post operative complication. | ||
| Keywords | ||
| Thyroid peroxidase; thyroglobulin | ||
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