Evaluation of the Inflammatory infiltrate in active vitiligo lesions | ||
| Minia Journal of Medical Research | ||
| Volume 30, Issue 1, March 2019, Pages 228-229 PDF (65.72 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjmr.2022.223017 | ||
| Authors | ||
| Sherif S. Awad1; Gabril M. Y.2; Ahmed A. Touni1 | ||
| 1Department of Dermatology and Venereology, Faculty of Medicine, Minia University, Minia, Egypt | ||
| 2Department of Pathology, London Health Sciences Centre and Western University, London, Ontario, Canada | ||
| Abstract | ||
| Background: Vitiligo is an autoimmune disease with episodes of activity and stability. Mononuclear cells infiltrate the vitiliginous skin with subsequent destruction of melanocytes are the hallmarks of vitiligo. Aim: to evaluate the mononuclear cell infiltrate in active vitiligo. Patients and methods: 30 active vitiligo patients were recruited, then perilesional, lesional and nonlesional skin were obtained and stained with hematoxylin and eosin. Results: The perilesional infiltrate was significantly higher in count than lesional and nonlesional ones. Also, the lesional infiltrate was significantly higher than nonlesional infiltrate. Conclusion: Perilesional skin of active vitiligo is by far the most representative area for the inflammatory infiltrate where active melanocytes destruction takes place. | ||
| Keywords | ||
| Vitiligo; Inflammatory infiltrate; mononuclear cell | ||
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