Impact of NQO1 C609T Polymorphism on The Outcome of Childhood Acute Lymphoblastic Leukemia from Zagazig University Hospital; Egypt | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 50, Volume 87, Issue 1, April 2022, Pages 1293-1296 PDF (539.75 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2022.223321 | ||
| Authors | ||
| Mohamed Eissa* ; Amal Ahmed Zidan; Ola Aly Hossein; Alaa A. Omran | ||
| KSA, Abha, 61412, P.O. Box 641 | ||
| Abstract | ||
| Background: The NAD (P) H: quinone oxidoreductase (NQO1) C609T polymorphism has been widely thought to be associated with the risk of acute leukemia. Objective: This case-control study aimed to assess the impact of NQO1 C609T gene polymorphism in childhood acute lymphoblastic leukemia (ALL). Patients and Method: The study was carried out on one hundred de novo ALL children and one hundred apparently healthy children. Routine genotyping of NQO1C609T gene polymorphism by PCR-RFLP was done for all subjects. Results: No statistically significant difference was observed between the patient group and control group as regards wild and polymorphic genotypes. However, there was a significant difference between ALL patients with wild and polymorphic genotypes regarding their immunophenotyping diagnosis (P=0.02) and FAB classification (P=0.01). There was also a significant difference between ALL patients with wild and polymorphic genotypes regarding their response to treatment. The complete remission in the wild genotype (CC) was 69.2% while in polymorphic genotypes (TT & CT) was 29.4% (P<0.05). Conclusion: The polymorphic genotype forms of the NQO1 C609T (CT and TT) are associated with decreased response to treatment. | ||
| Keywords | ||
| NQO1; TT; CT; ALL; genotypes | ||
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