EVALUATION OF MATERNAL SERUM PENTRAXIN 3 AS A NOVEL DIAGNOSTIC BIOMARKER IN GESTATIONAL DIABETES MELLITUS | ||
| ALEXMED ePosters | ||
| Article 1, Volume 4, Issue 1, March 2022, Pages 46-47 | ||
| Document Type: Preliminary preprint short reports of original research | ||
| DOI: 10.21608/alexpo.2022.124724.1377 | ||
| Authors | ||
| Mohamed Yousri Khamis1; Manal Shafik Swelem2; Marwa Ibrahim Abdelhalim Khedr3; Bassant Saeed Basyouni Ibrahim* 1 | ||
| 1Department of Obstetrics and Gynecology, Faculty of Medicine, Alexandria University | ||
| 2Department of obstetrics and gynaecology, Faculty of medicine | ||
| 3Department of Medical Biochemistry, Faculty of Medicine, Alexandria University | ||
| Abstract | ||
| Gestational diabetes mellitus (GDM) is the type of glucose intolerance that develops in the second and third trimester of pregnancy, resulting in hyperglycemia of variable severity. It is the most common metabolic disorder of pregnancy. The oral glucose tolerance test (OGTT) is considered the cornerstone of the diagnosis of gestational diabetes mellitus (GDM). Earlier detection of GDM may lead to improved management, possibly preventing pregnancy complications. Thus, the identification of sensitive and specific biomarkers, which may offer potential for risk prediction and intervention strategies, became a major focus in GDM research. Pentraxins are a superfamily of evolutionarily conserved molecules with multi-functional roles in innate immunity and inflammation. They are essential constituents of the humoral arm of innate immunity and represent a superfamily of highly conserved acute phase proteins. Pentraxin 3 (PTX3) is the prototype of the long pentraxin subfamily. In recent years, chronic subclinical inflammation is considered to have a potential role in the pathogenesis of hyperglycemia and pentraxin 3 (PTX3) as an inflammatory mediator, is correlated with the process of insulin resistance and its level is also increased in diabetes mellitus and diabetic nephropathy. The OGTT is beloved by very few, and validation of alternative, less cumbersome strategies for diagnosis and classification of GDM are needed. | ||
| Keywords | ||
| Gestational diabetes mellitus (GDM); oral glucose tolerance test (OGTT); Pentraxin 3 (PTX3) | ||
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