Response to Hepatitis B Vaccine in Chronic Hepatitis C Patients Treated with Direct Acting Antivirals | ||
| Benha Medical Journal | ||
| Article 2, Volume 39, Issue 2, July and August 2022, Pages 346-356 PDF (712.14 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bmfj.2022.114488.1525 | ||
| Authors | ||
| Said EM1; Dalia Nour El Din2; Mona Ahmed Elawady3; Shaimaa Yehia Ragab* 1; Tamer E El-Eraky1 | ||
| 1Hepatology,gastroentrology and infectious disease,Faculty of Medicine-Benha University | ||
| 2Clinical and Chemical Pathology Benha Faculty of Medicine- Benha University | ||
| 3Public Health and Community Medicine Department,Benha Faculty of Medicine- Benha University | ||
| Abstract | ||
| Background and Aims: In Egypt, compulsory vaccination against hepatitis B virus (HBV) infection started in 1992. Patients with chronic hepatitis C (CHC) should be vaccinated against HBV. The aim was to assess the response to HBV vaccine in CHC patients treated with direct acting antivirals (DDAs) in comparison to treatment-naive patients and healthy subjects. Method: This prospective study was carried out on 360 consecutive adult subjects subdivided into 3 groups. Group I included 150 CHC patients who vaccinated after getting sustained virologic response (SVR) following treatment with DAAs. Group II comprised 110 CHC treatment- naive patients while the control group comprised 100 healthy subjects. Three intramuscular 20 µg doses (at 0, 1 & 6 months) of HBV-vaccine (rDNA) were administered, HBs Ab titres were evaluated 6 – 8 weeks after the 3rd dose. Results: CHC patients (treated or treatment-naïve) had highly significant lower mean HBs Ab titre than controls. Twelve patients in group I (8%) had no response to HBV vaccine in comparison to 4.5% in group II and 1% controls. About 83.3%in group I compared to 85.5% in group II and 98% controls had a good response. In CHC treated patients, HBs Ab titre was negatively associated with FIB-4 score, fibrosis stage and ALT levels while positively associated with platelet count. The fibrosis stage was the most significant predictor of weak response. Conclusion: CHC Patients demonstrate a significantly weak response to HBV vaccine. Concomitant DAAs treatment does not influence response. | ||
| Keywords | ||
| Hepatitis B virus; Hepatitis C virus; Hepatitis B vaccine | ||
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