Abdel-Rahman, I., Abdel-Aziz, M., Hayallah, A., Abuo-Rahma, G. (2021). Fluoroquinolone Mannich bases as promising biologically beneficial molecules. test, 32(2), 21-35. doi: 10.21608/mjmr.2021.228161
Islam M. Abdel-Rahman; Mohamed Abdel-Aziz; Alaa Hayallah; Gamal El-Din A. Abuo-Rahma. "Fluoroquinolone Mannich bases as promising biologically beneficial molecules". test, 32, 2, 2021, 21-35. doi: 10.21608/mjmr.2021.228161
Abdel-Rahman, I., Abdel-Aziz, M., Hayallah, A., Abuo-Rahma, G. (2021). 'Fluoroquinolone Mannich bases as promising biologically beneficial molecules', test, 32(2), pp. 21-35. doi: 10.21608/mjmr.2021.228161
Abdel-Rahman, I., Abdel-Aziz, M., Hayallah, A., Abuo-Rahma, G. Fluoroquinolone Mannich bases as promising biologically beneficial molecules. test, 2021; 32(2): 21-35. doi: 10.21608/mjmr.2021.228161

Fluoroquinolone Mannich bases as promising biologically beneficial molecules

Minia Journal of Medical Research
Volume 32, Issue 2, April 2021, Pages 21-35    PDF (356.21 K)
Document Type: Original Article
DOI: 10.21608/mjmr.2021.228161
Authors
Islam M. Abdel-Rahman1; Mohamed Abdel-Aziz2; Alaa Hayallah3; Gamal El-Din A. Abuo-Rahma2
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Deraya University, 61519-New Minia, Minia, Egypt.
2Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University
3Department of pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut
Abstract
Mannich bases, a structurally heterogeneous aminomethyl functionality, found numerous applications
in medicinal chemistry field. Fluoroquinolones-Mannich bases here is discussed, with prominence on
the correlation between structure and biological activity as it could be responsible for enhancing
physicochemical properties of fluoroquinolones. The review covers broadly the literature works that
correlated fluoroquinolones-Mannich bases cytotoxicity activity as anticancer agents rather than their
antibacterial activity. The most applicable studies on the activity of fluoroquinolones-Mannich bases
as potential antimycobacterial candidates and antiviral agents have been included as well. This
contemporary review considers a first kernel for upcoming exertions in designing and synthesis of
more Fluoroquinolone -Mannich bases.

Keywords
Fluoroquinolones; Mannich bases; Antibacterial; Anticancer; Antimycobacterial
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