Enhancement of Hypolipidemic Effect of Atorvastatin Calcium via Floating Microspheres | ||
| Zagazig Journal of Pharmaceutical Sciences | ||
| Article 2, Volume 31, Issue 1, June 2022, Pages 14-24 PDF (668.54 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zjps.2022.124307.1026 | ||
| Author | ||
| Al Zahraa G. Al Ashmawy* | ||
| Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt. | ||
| Abstract | ||
| The purpose of this study was to investigate the influence of hypolipidemic atorvastatin calcium (ATC) floating microspheres on the LDL and HDL level in rabbit blood. Floating microspheres-loaded ATC were prepared via emulsion solvent evaporation method using Eudragit S100 as polymer. The effect of certain variables including drug: polymer ratio, stirring rate, emulsifier concentration and internal: external phase volume ratio on the floating microspheres formulations were performed. Evaluation of floating microspheres was done using particle size analysis, percentage yield, in-vitro buoyancy, entrapment efficiency determination, optical microscopy, in-vitro drug release studies, Thermal analysis (DSC) and Fourier transform infrared spectroscopy (FTIR). The prepared microspheres showed a good floating ability. The Floating microspheres formulation No (F5) revealed the highest %drug released (66%) after 8 h. Furthermore, F5 significantly decreased the blood LDL and increased HDL in comparison with the market drug (ATOR ®) and it succeeded in lowering the rabbit's blood total cholesterol level by 74.42%. | ||
| Keywords | ||
| Atorvastatin calcium; Eudragit S100; floating microspheres; HDL; LDL and total lipid | ||
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