Role of Pumpkin and Linseed Oils in Attenuating the Nephrotoxicity of Bisphenol-A in Mice: Biochemical, Genetic and Histopathological studies | ||
| Egyptian Journal of Chemistry | ||
| Volume 66, Issue 1, January 2023, Pages 291-301 PDF (1.26 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2022.122316.5475 | ||
| Authors | ||
| Osama Elhamalawy1; Fathia Al-Anany2; Aida El makawy* 3 | ||
| 1Department of Environment and Bio-Agriculture, Faculty of Agriculture, Al-Azhar University | ||
| 2Department of Biological and Environmental Science, Faculty of Home Economics, Al-Azhar University, | ||
| 3Cell Biology Department, Biotechnology Research Institute, National Research Centre | ||
| Abstract | ||
| Edible plant oils have been made known to be exciting sources of bioactive compounds making them a suitable alternative in the management of some human diseases. Pumpkin and linseed oils are high in Omega-3 & Omega-6 are considered the utmost vital essential fatty acids that the body cannot create and are considered crucial for health. Bisphenol-A (BPA) plays a role in the development of chronic kidney disease, particularly in developing countries with high levels of pollution. The toxicity of BPA in mice kidney cells and the attenuating role of pumpkin and linseed oils against the deleterious effects of BPA were assessed using kidney function analysis, comet assay for DNA damage detection, and histopathological examination. In an experimental mouse model, pumpkin and linseed oils were administered orally by gavage before or together with BPA administration once a day for four weeks. BPA increased the levels of kidney function markers and the administration of pumpkin and linseed oils resulted in a successful recovery to the normal levels of these metabolites. Our results indicate that pumpkin and linseed oils can increase DNA integrity and ameliorate the histopathological defects in the kidney tissues of BPA-treated mice. The current study found that pumpkin and linseed oils have promising attenuating activity against the unwanted properties of BPA. | ||
| Keywords | ||
| Nutraceutical oils; Bisphenol-A; Kidney function; Genotoxicity; Histopathology | ||
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