Khaled, A., Mohamed, M., Gheith, A., Mohamed, H., abdellatief, G., Fouad, R., Tantawy, A., Melad, E., Magdy, H., Elkordi, Y., Mohamed, A. (2022). Mechanism of actions of some common toxic agents causing toxic cardiomyopathy. test, 28(6), 1184-1188. doi: 10.21608/zumj.2022.125953.2492
Abdelazem Khaled; Meriet Ahmed Mohamed; Ahmed Hamdy Gheith; Hala Mohamed; Goda Ibrahim abdellatief; Rana Fouad; Abdulrahman Mohamed Tantawy; Ereny Melad; Haitham Magdy; Youssef Hesham Elkordi; Ahmed Adel Mohamed. "Mechanism of actions of some common toxic agents causing toxic cardiomyopathy". test, 28, 6, 2022, 1184-1188. doi: 10.21608/zumj.2022.125953.2492
Khaled, A., Mohamed, M., Gheith, A., Mohamed, H., abdellatief, G., Fouad, R., Tantawy, A., Melad, E., Magdy, H., Elkordi, Y., Mohamed, A. (2022). 'Mechanism of actions of some common toxic agents causing toxic cardiomyopathy', test, 28(6), pp. 1184-1188. doi: 10.21608/zumj.2022.125953.2492
Khaled, A., Mohamed, M., Gheith, A., Mohamed, H., abdellatief, G., Fouad, R., Tantawy, A., Melad, E., Magdy, H., Elkordi, Y., Mohamed, A. Mechanism of actions of some common toxic agents causing toxic cardiomyopathy. test, 2022; 28(6): 1184-1188. doi: 10.21608/zumj.2022.125953.2492

Mechanism of actions of some common toxic agents causing toxic cardiomyopathy

Zagazig University Medical Journal
Article 2, Volume 28, Issue 6, November 2022, Pages 1184-1188    PDF (258.22 K)
Document Type: Review Articles
DOI: 10.21608/zumj.2022.125953.2492
Authors
Abdelazem Khaled1; Meriet Ahmed Mohamed1; Ahmed Hamdy Gheith1; Hala Mohamed1; Goda Ibrahim abdellatief2; Rana Fouad2; Abdulrahman Mohamed Tantawy2; Ereny Melad1; Haitham Magdy2; Youssef Hesham Elkordi* 3; Ahmed Adel Mohamed1
1Faculty of medicine, Zagazig University, Zagazig, Sharkia, Egypt
2faculty of medicine, zagazig university, zagazig, sharkia, egypt
3zagazig university faculty of medicine
Abstract
Background: Toxic cardiomyopathy is related to heart failure in many cases and may lead to death. We focused on the mechanisms by which some common toxic agents cause cardiomyopathy. We searched in articles, case reports, experimental and clinical studies on this topic
Our results have shown that the heart or the cardiovascular system is one of the most affected systems by toxic agents. We summarized studies which mentioned some common cause such as; "Anti-cancer drugs", "Anti-diabetic drugs", "Cocaine", "Ethanol", "Heavy Metals", and "Digitalis drugs” and their mechanism of action inducing cardiotoxicity.. We concluded that mechanisms underlying toxic cardiomyopathy are complicated and variable. However, they generally include disruption of cell bioenergetics and intracellular calcium handling. It is also involved in: production of reactive oxygen species (ROS), development of oxidative stress and apoptosis induction.
Conclusion: Toxic agents have a very harmful effect on the heart producing cardiomyopathy and heart failure. A lot of drugs and environmental toxins can produce cardiotoxicity including; anti-cancer drugs, anti-diabetic drugs, cocaine, ethanol, CO, and heavy metals their mechanisms of action are complicated and included many factors.
Keywords
"Cardiomyopathy"; "toxicity; "Heart Failure" "toxic agent; "Digitalis"
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