Evaluation of Interleukin-6 and Interleukin-1 β Levels in Febrile Status Seizures | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 126, Volume 87, Issue 1, April 2022, Pages 1743-1747 PDF (604.52 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2022.229733 | ||
| Authors | ||
| Samar Elhady Mosa Fadl* ; Ahmad Galal Siam; Ahmad Hosny Mohamad; Ahmad Abdelsabour Mohamad | ||
| Abstract | ||
| Background: Seizures triggered by fever are known as febrile seizures, and they are the most common form in children. The cause of febrile seizures is still a mystery, even though numerous studies have been carried out. Researchers have found cytokines may play an important role in the development of febrile seizures. Objective: to evaluate the role of Interleukin-6 and interleukin-1β levels in febrile status epilepticus. Patients and methods; This was a prospective case-control study, conducted at the Neurological Unit of the Pediatric Department, Faculty of Medicine, Zagazig University, Sharkia, Egypt on 52 children (26 in each group), plasma cytokine (IL-6 and IL-1β) levels were detected as a main part of the initial study design. Results: A significant difference was found between both groups as regard IL-6 and IL-1β. Conclusion: A genetic risk factor for fever-related seizures in children may be associated with promotor variations in IL-1 β genes rather than IL-6 or HMGB1 genes. | ||
| Keywords | ||
| Cytokines; Seizures; IL-6; IL-1β | ||
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