Salama, S., Barrak, A., Hammad, A., Abd-Alkader, A. (2019). The Role of Visceral Fat, IL-6, Adiponectin and Leptin Levels on Reflux Esophagitis in Obese Patients. test, 74(2), 262-269. doi: 10.21608/ejhm.2019.22984
Salem Soliman Ahmed Salama; Abd El-Monem Mohamed Barrak; Amin Mahmoud Hejazi Kamel Soliman Hammad; Ahmed Farag Abd-Alkader. "The Role of Visceral Fat, IL-6, Adiponectin and Leptin Levels on Reflux Esophagitis in Obese Patients". test, 74, 2, 2019, 262-269. doi: 10.21608/ejhm.2019.22984
Salama, S., Barrak, A., Hammad, A., Abd-Alkader, A. (2019). 'The Role of Visceral Fat, IL-6, Adiponectin and Leptin Levels on Reflux Esophagitis in Obese Patients', test, 74(2), pp. 262-269. doi: 10.21608/ejhm.2019.22984
Salama, S., Barrak, A., Hammad, A., Abd-Alkader, A. The Role of Visceral Fat, IL-6, Adiponectin and Leptin Levels on Reflux Esophagitis in Obese Patients. test, 2019; 74(2): 262-269. doi: 10.21608/ejhm.2019.22984

The Role of Visceral Fat, IL-6, Adiponectin and Leptin Levels on Reflux Esophagitis in Obese Patients

The Egyptian Journal of Hospital Medicine
Article 6, Volume 74, Issue 2, January 2019, Pages 262-269    PDF (624.31 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2019.22984
Authors
Salem Soliman Ahmed Salama; Abd El-Monem Mohamed Barrak; Amin Mahmoud Hejazi Kamel Soliman Hammad; Ahmed Farag Abd-Alkader*
Internal Medicine Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
Abstract
Background: Gastroesophageal reflux disease (GERD) is one of the most common problems encountered in clinical practice today. The pathophysiology of GERD is complex, involving diverse factors. Aim of the work: was to assess the role of visceral fat and IL-6, adiponectin and leptin levels on reflux esophagitis in obese patients. Patients and Methods: This prospective observational case-control study included a total of 90 participants; 60 patients with reflux esophagitis and 30 age and sex-matched healthy controls. Evaluation of the Role of Visceral Fat, IL-6, Adiponectin and Leptin Levels on Reflux Esophagitis in Obese Patients was done. Results: An overall 90 patients were enrolled in this study, 50 males and 40 females, were assorted into three groups, obese and had GERD group, non-obese and had GERD, included 30 patients (33.3%),17 males (56.7%) and 13 females (43.3%), and control group, included 30 patients (33.3%),18 males (60%) and 12 females (40%). The mean levels of body mass index, weight circumference, fasting-plasma glaucous, two hours post-prandial plasma glucose, Creatinine, liver enzymes, and lipid parameters were elevated in obese group when compared with non-obese and control groups. Consequently, the mean levels of leptin and interleukin-6 were high in obese group in comparison with other groups. Interestingly, the mean level of adiponectin was high in non-obese group in comparison with obese and control groups. Conclusion: Inflammatory cytokines, adipokines, and visceral fat referring abdominal obesity had an association with reflux esophagitis.
Keywords
reflux esophagitis; Obesity; adiponectin; leptin; visceral fat
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