Oraby, N., Hassan, A., Mansour, M., Arafa, M., Ibrahim, E., Talkhan, O. (2022). Protective and detoxificating effects of selenium nanoparticles and thyme extract on the aflatoxin B1 in rabbits. test, 100(3), 284-293. doi: 10.21608/ejar.2022.111578.1214
Noha Hassan Oraby; Atef Abdel-aziz Hassan; Mogda Kamel Mansour; Mahmoud Mohamed Arafa; Essam Ibrahim; Ola Fouad Talkhan. "Protective and detoxificating effects of selenium nanoparticles and thyme extract on the aflatoxin B1 in rabbits". test, 100, 3, 2022, 284-293. doi: 10.21608/ejar.2022.111578.1214
Oraby, N., Hassan, A., Mansour, M., Arafa, M., Ibrahim, E., Talkhan, O. (2022). 'Protective and detoxificating effects of selenium nanoparticles and thyme extract on the aflatoxin B1 in rabbits', test, 100(3), pp. 284-293. doi: 10.21608/ejar.2022.111578.1214
Oraby, N., Hassan, A., Mansour, M., Arafa, M., Ibrahim, E., Talkhan, O. Protective and detoxificating effects of selenium nanoparticles and thyme extract on the aflatoxin B1 in rabbits. test, 2022; 100(3): 284-293. doi: 10.21608/ejar.2022.111578.1214

Protective and detoxificating effects of selenium nanoparticles and thyme extract on the aflatoxin B1 in rabbits

Egyptian Journal of Agricultural Research
Article 1, Volume 100, Issue 3, September 2022, Pages 284-293    PDF (839.2 K)
Document Type: Original Article
DOI: 10.21608/ejar.2022.111578.1214
Authors
Noha Hassan Oraby* 1; Atef Abdel-aziz Hassan2; Mogda Kamel Mansour3; Mahmoud Mohamed Arafa4; Essam Ibrahim5; Ola Fouad Talkhan6
1Animal Health Research Institute٫agriculural research center (ARC) Nadi el Said Street,Dokki Dokii
2Animal Health Research Institute (AHRI),Agriculture Research Center (ARC),Cairo,Egypt
3Animal Health Research institute, agricultural Research center (ARc), Dokii, Egypt
4Animal Health Research Institute, Agricultural research Center (ARC), Dokii, Egypt
5Animal Health Research Institute, Agriculture Research Centre, Dokki, Cairo, Egypt
6Animal Health Research Institute, Agriculture Research Centre, Regional Laboratory at Minufiya Governorate, Egypt
Abstract
Nanotechnology's application in biomedicine has piqued the curiosity of all authorities throughout the world. Different fungus species and aflatoxins were recovered from rabbit feed at significant quantities up to 300 ppb in this investigation. Selenium nanoparticles (Se-NPs) were generated using a chemical process, described briefly, and utilized to reduce the harmful effects of aflatoxicosis in rabbits. Biochemical parameters in tissues and sera of all aflatoxicated rabbits revealed that it caused the development of reactive oxygen species (ROS), an increase in nitric oxide levels, and malonaldehyde levels. While Total Antioxidant Capacity (TAC) activities are reduced, additional antioxidants in rabbit homogenate liver tissues will be found. In aflatoxicosis, decreased serum retinol and a-tocopherol were also found. For aflatoxicated rabbits, oral treatment of SeNPs and thyme restored these alterations to normal levels. Furthermore, SeNPs and thyme triggered the breakdown of AFB1 residues in liver tissues, suggesting that SeNPs and thyme can be introduced to animal feeds as antioxidants with good effects on animal health and mycotoxins removal.
Keywords
Nanotechnology; Se-NPs; Aflatoxicosis; Thyme; Antioxidant; fungi
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