Abdel Fattah, A., Khowailed, A., Gaber, S. (2021). Correlation between Serum Inflammatory and Oxidative Stress Markers with Blood Pressure in Preeclampsia. test, 32(2), 54-66. doi: 10.21608/mjmr.2021.231546
Amira A. Abdel Fattah; Akef A. Khowailed; Safy S. Gaber. "Correlation between Serum Inflammatory and Oxidative Stress Markers with Blood Pressure in Preeclampsia". test, 32, 2, 2021, 54-66. doi: 10.21608/mjmr.2021.231546
Abdel Fattah, A., Khowailed, A., Gaber, S. (2021). 'Correlation between Serum Inflammatory and Oxidative Stress Markers with Blood Pressure in Preeclampsia', test, 32(2), pp. 54-66. doi: 10.21608/mjmr.2021.231546
Abdel Fattah, A., Khowailed, A., Gaber, S. Correlation between Serum Inflammatory and Oxidative Stress Markers with Blood Pressure in Preeclampsia. test, 2021; 32(2): 54-66. doi: 10.21608/mjmr.2021.231546

Correlation between Serum Inflammatory and Oxidative Stress Markers with Blood Pressure in Preeclampsia

Minia Journal of Medical Research
Volume 32, Issue 2, April 2021, Pages 54-66    PDF (411.56 K)
Document Type: Original Article
DOI: 10.21608/mjmr.2021.231546
Authors
Amira A. Abdel Fattah1; Akef A. Khowailed2; Safy S. Gaber1
1Department of Medical Physiology, Faculty of Medicine, Beni-Suef University, Egypt.
2Department of Medical Physiology, Kasr Al-Aini Faculty of Medicine, Cairo University, Egypt.
Abstract
Objectives: To evaluate the serum pro-inflammatory cytokines (Tumor necrosis alpha (TNF α)), 
oxidative stress marker(Malondialdehyde(MDA)) and serum antioxidant biomarker (Superoxide 
dismutase(SOD)) and study their correlations with blood pressure (BP) in preeclampsia (PE).
Methods: Fifty pregnant women (18 - 35 years old) were divided into two groups each with 25 
pregnant women: preeclampsia group and control group. Results: Blood pressure, mean serum TNF 
α, and MDA were significantly higher, while, the mean serum value of SOD was significantly lower in 
the pregnant women with preeclampsia than in the control pregnant women. Also, there was a 
significant positive correlation between TNF α, MDA, and BP. Conclusion: Elevated both serum TNF 
α, MDA and decreased SOD are the possible mechanisms involved in the pathogenesis of PE.
Early detection of PE allows for planning of appropriate monitoring of PE and for prevention of 
complications.

Keywords
Preeclampsia; ROS; TNF α; Antioxidants; Oxidative stress
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