Evaluation of the role of 24h urinary protein in Diagnosis of Lupus Nephritis Activity | ||
| Minia Journal of Medical Research | ||
| Volume 32, Issue 2, April 2021, Pages 77-79 PDF (357.65 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjmr.2021.231549 | ||
| Authors | ||
| Hanan M. Kamel1; Manal M. S.2; Nagwa I. O.1; Dina A. Beshara2 | ||
| 1Department of Clinical pathology, Faculty of Medicine, Minia University, Egypt. | ||
| 2Department of Clinical pathology, Faculty of Medicine, Minia University, Egypt | ||
| Abstract | ||
| Background: Lupus nephritis (LN) is a form of glomerulonephritis and constitutes one of the most severe organ manifestations of SLE. LN is histologically classified into six distinct classes that represent different manifestations and severities of renal involvement in SLE. Most patients with SLE who develop LN do so within 5 years of an SLE diagnosis, although it is not uncommon for LN to develop at later times. In many cases, LN is the presenting manifestation that results in the diagnosis of SLE. Urinary protein excretion in a 12-h or 24-h urine collection provides the best estimate of proteinuria. For practical reasons, urinary protein-to creatinine ratio in early morning or random daytime urine samples has replaced urinary protein excretion in 24-h urine collections in many centres, although this approach has not been carefully validated. Objectives: This work aims to evaluate the role of proteinuria in Diagnosis of Lupus Nephritis. Methods: The study was conducted on 60 cases of Systemic Lupus Erythmatosis, The age of patients ranged from 27.5 to 43 patients were subjected to routine and special investigations which included C.B.C (complete blood count) using celltac G, Nihon KHODEN CORPORATION, AUTOMATED HEMATOLOGY ANALYZER, japan). And renal functions including blood urea and serum creatinine using auto-analyzer SELECTRA, ELITech Group, clinical chemistry automation systems, Finland). Results: Patients with persistent proteinuria, such as protein excretion of more than 0.7–0.8 g daily 1 year after treatment initiation or kidney function deterioration despite adequate treatment (‘refractory LN’) should be assessed for other possible causes, including potential nephrotoxic side effects of medications. Conclusion: 24h urinary protein is considered corner stone in the Diagnosis of Lupus Nephritis Activity. | ||
| Keywords | ||
| Lupus Nephritis; Diagnosis | ||
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