Experimental studies on whole bee venom inactivated Rift Valley fever vaccine candidate in vitro | ||
| Egyptian Journal of Chemistry and Environmental Health | ||
| Volume 1, Issue 1, November 2015, Pages 274-290 PDF (705.67 K) | ||
| Document Type: Scientific and Research | ||
| DOI: 10.21608/ejceh.2015.233102 | ||
| Authors | ||
| Samia Ahmed Kamal* 1; Haggag E. Bedair2; Ragaa ASR Faisa1 | ||
| 1Animal Health Research Institute (AHRI), Egypt | ||
| 2Plant Protection Institute, (ARC) | ||
| Abstract | ||
| In regard to the safety concerns about RVF vaccines, this work aim to use the safest natural product to inactivate the Rift Valley fever virus (RVFV). Also, our study on the effect of honeybee (Apis mellifera L) venom on some types of cell lines cultures showed it cause apoptosis at lower concentrations and digestion of the cells at relatively higher concentration. In this study, honey bee venom is used as inactivant of Rift Valley fever virus (RVFV). Beside in vitro study on this inactivated RVFV it was injected in rabbits and mice to investigate its behavior in vivo. The results showed that rabbits and mice immunized with this RVFV inactivated vaccine exhibited satisfied antibodies response. Pathological investigation of the immunized mice showed that bee venom inactivated RVF vaccine didn't cause any side effects in liver, kidneys, brain and spleen. Therefore, honey bee (Apis mellifera) venom as a natural product can be used as RVFV inactivant and recommended for animal's vaccines. | ||
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