Abdel-Aziz, N., Badawy, A., El-Gamal, A., El-Belely, E., Hammad, A., Zakria, A. (2022). The Possible Impact of Spirulina and Chlorella on some Hematological and Biochemical Aspects in Irradiated Rats. test, 55(3), 130-137. doi: 10.21608/ajnsa.2022.125836.1558
Nahed Abdel-Aziz; Ahmad Badawy; Ahmad El-Gamal; Ehab El-Belely; Aly Hammad; Abeer Zakria. "The Possible Impact of Spirulina and Chlorella on some Hematological and Biochemical Aspects in Irradiated Rats". test, 55, 3, 2022, 130-137. doi: 10.21608/ajnsa.2022.125836.1558
Abdel-Aziz, N., Badawy, A., El-Gamal, A., El-Belely, E., Hammad, A., Zakria, A. (2022). 'The Possible Impact of Spirulina and Chlorella on some Hematological and Biochemical Aspects in Irradiated Rats', test, 55(3), pp. 130-137. doi: 10.21608/ajnsa.2022.125836.1558
Abdel-Aziz, N., Badawy, A., El-Gamal, A., El-Belely, E., Hammad, A., Zakria, A. The Possible Impact of Spirulina and Chlorella on some Hematological and Biochemical Aspects in Irradiated Rats. test, 2022; 55(3): 130-137. doi: 10.21608/ajnsa.2022.125836.1558

The Possible Impact of Spirulina and Chlorella on some Hematological and Biochemical Aspects in Irradiated Rats

Arab Journal of Nuclear Sciences and Applications
Article 14, Volume 55, Issue 3, July 2022, Pages 130-137    PDF (822.02 K)
Document Type: Original Article
DOI: 10.21608/ajnsa.2022.125836.1558
Authors
Nahed Abdel-Aziz* 1; Ahmad Badawy2; Ahmad El-Gamal3; Ehab El-Belely3; Aly Hammad4; Abeer Zakria5
1Radiation Biology Department, National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority Cairo, Egypt.
2Radiation Microbiology Department, National Centre for Radiation Research and Technology, Egyptian Atomic Energy Authority, Cairo, Egypt.
3Botany and Microbiology Department, Faculty of Science, Al-Azhar University, Cairo, Egypt.
4Radiation Microbiology Department, National Centre for Radiation Research and Technology, Egyptian Atomic Energy Authority, Cairo, Egypt
5E.A.E.A
Abstract
Background: Patients undergoing radiotherapy may suffer from many harmful effects including gut microbiota injury, therefore, the use of exogenous probiotics is suggested to reduce these effects. Aim: The present study aimed to determine the possible protective effect of Spirulina platensis and Chlorella vulgaris against radiation-induced hematological and biochemical disturbances in male albino rats. Materials and Methods: Spirulina or chlorella was administered orally at a dose level of 300 mg/kg body weight daily for one week before and one week after the exposure to gamma radiation (6Gy, single dose). Results: Whole-body gamma-irradiation induced a significant decrease in total leukocyte count, red blood cell count, hemoglobin concentration, hematocrit value and platelets count, compared to their corresponding values of the control group. A significant increase in alanine aminotransferase (ALT) activity, marker of liver damage, and a non-significant increase in urea and creatinine levels, markers of kidney function was is observed. Spirulina or chlorella administration pre- and post-irradiation has significantly attenuated the radiation-induced disturbances in the studied parameters. Conclusion: oral supplementation of spirulina or chlorella may afford protection against radiation-induced detrimental effect and may preserve the tissue integrity and the functions of different organs in the body.
Keywords
γ-radiation; Spirulina platensis; Chlorella vulgaris; Blood; Liver; Kidney
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