EFFECT OF LACTOBACILLUS ACIDOPHILUS ON TRICHINELLA SPIRALIS MUSCLE LARVAE IN EXPERIMENTALLY INFECTED MICE COMPARED TO ITS EFFECT WHEN COMBINED WITH ALBENDAZOLE AND/OR NITAZOXANIDE | ||
| Journal of the Egyptian Society of Parasitology | ||
| Article 13, Volume 52, Issue 1, May 2022, Pages 107-116 PDF (1.38 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jesp.2022.235818 | ||
| Authors | ||
| NARDEEN ZAKKA BOCKTOR1; MOHAMED EL-SAIED2; NAGLAA F. A. IMAM1 | ||
| 1Department of Medical Parasitology, Faculty of Medicine, Cairo University, Egypt | ||
| 2Department of Pathology, Faculty of Veterinary Medicine, Cairo University | ||
| Abstract | ||
| This study evaluated the therapeutic and synergistic effects of Lactobacillus acidophilus (L. acidophilus), a probiotic, and nitazoxanide (NTZ) as compared to the used, albendazole (ABZ), as single therapy and in combination. ABZ/L. acidophilus-treated group showed the highest reduction of encysted larvae (92.5%) as compared to control and to ABZ-treated mice. Also, NTZ treatment showed a significant decrease in larval counts compared to control (40.95%), which was comparable to that produced by L. acidophilus single therapy. But, combined NTZ with L. acidophilus caused a significantly higher reduction of larvae (56.62%) highlighted synergistic abilities of both. Histopathological examination showed marked decrease in larval counts and inflammatory reactions in ABZ/L. acidophilus-treated group. Combined L. acidophilus with other therapeutics caused increased eosinophilia degeneration and larval replacement. | ||
| Keywords | ||
| Trichinella spiralis larvae; Lactobacillus acidophilus; Nitazoxanide; Albendazole | ||
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