Hamed, A., El Hadidy, K., Salem, M. (2022). Ferritin as a marker of Insulin Resistance in Diabetic Patients. test, 3(2), 110-120. doi: 10.21608/ejmr.2022.237765
Ahmed Mohey Eldien Hamed; Khaled EL Sayed El Hadidy; Mohammed Nabil Salem. "Ferritin as a marker of Insulin Resistance in Diabetic Patients". test, 3, 2, 2022, 110-120. doi: 10.21608/ejmr.2022.237765
Hamed, A., El Hadidy, K., Salem, M. (2022). 'Ferritin as a marker of Insulin Resistance in Diabetic Patients', test, 3(2), pp. 110-120. doi: 10.21608/ejmr.2022.237765
Hamed, A., El Hadidy, K., Salem, M. Ferritin as a marker of Insulin Resistance in Diabetic Patients. test, 2022; 3(2): 110-120. doi: 10.21608/ejmr.2022.237765

Ferritin as a marker of Insulin Resistance in Diabetic Patients

Egyptian Journal of Medical Research
Article 7, Volume 3, Issue 2, April 2022, Pages 110-120    PDF (391.45 K)
Document Type: Original Article
DOI: 10.21608/ejmr.2022.237765
Authors
Ahmed Mohey Eldien Hamed; Khaled EL Sayed El Hadidy; Mohammed Nabil Salem
Internal Medicine Department, Faculty of Medicine, Beni-Suef University, Egypt.
Abstract
Backgroud : Insulin resistance is a pathogenic hallmark of type 2 diabetes mellitus (T2DM).Serum ferritin, a predominant iron-storage protein and a biomarker of iron stores, are elevated in persons with prevalent diabetes as compared with non-diabetic controls and correlate with impaired fasting glucose levels.High ferritin levels have been associated with the metabolic syndrome and measures of insulin resistance .The aim of the current study : is to measure Serum Ferritin in patients with type 2 diabetes in Beni- Suef governorate and to study the relationship between serum Ferritin and Insulin Resistance. Patients and Methods : This study involved 40 patients with type 2 diabetes (24 females and 16 males) and 20 healthy adults (12 females and 8 males) served as a control group. All groups included in this study were subjected to Full History Taking, Clinical Examination including (BMI & Waist Circ.) and Laboratory Investigation including ( FPG, HbA1c, Serum Ferritin and Fasting Serum Insulin & measuring HOMA-IR).Results : Ferritin showed a statistically significant correlation with Waist Circ., FPG, HbA1c, Fasting Serum Insulin and Insulin Resistance (HOMA-IR) in the diabetic group (P < 0.05) .Conclusion: Serum ferritin can be used as a marker  of insulin resistance syndrome in diabetics
Keywords
Ferritin; Insulin Resistance; Type 2 Diabetes
References
  1. Chang Hee Jung, Min Jung Lee, Jenie Yoonoo Hwang et al., Elevated Serum Ferritin Level Is Associated with the Incident Type 2 Diabetes in Healthy Korean Men: A 4 Year Longitudinal Study. PLoS One. 2013; 8(9): e75250. 
  2. Higgins T, Eckfeldt JH, Barton JC et al. Hemoglobin, iron and bilirubin.In: Burtis CA, Ashwood ER, Bruns DE editors. Tietz textbook of clinical chemistry and molecular diagnostics 5th ed. St. Louis: Elsevier Saunders, 2012 ; 985 – 1030.
  3. Berkhan LInterpretation of an elevated serum ferritin NZFP 2002;Volume 29 Number 1.
  4. Kim CH, Kim HK, Bae SJ, et al. Association of elevated serum ferritin concentration with insulin resistance and impaired glucose metabolism in Korean men and women. Metabolism 2011; 60:414–420.
  5. Wrede CE, Buettner R, Bollheimer LC, et al,. Association between serum ferritin and the insulin resistance syndrome in a representative population. European Journal of Endocrinology 2006; 154 333–340.
  6. Nick Wlazlo, Marleen M.J., Isabel Ferreira, et al .Iron Metabolism Is Associated With Adipocyte Insulin Resistance and Plasma Adiponectin. Diabetes Care. Feb 2013; 36(2): 309–315.
  7. Houstis N, Rosen ED and Lander ES. Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 2006; 440:944–948.
  8. Pietrangelo A. Hereditary hemochromatosisa new look at an old disease. N Engl J Med 2004; 350:2383–2397.
  9. Forouhi NG, Harding AH, Allison M, et al. Elevated serum ferritin levels predict new-onset type 2 diabetes: results from the EPIC-Norfolk prospective study. Diabetologia 2007;50:949–956.
  10. Lee BK, Kim Y and Kim YI. Association of serum ferritin with metabolic syndrome and diabetes mellitus in the South Korean general population according to the Korean National Health and Nutrition Examination Survey 2008. Metabolism 2011; 60:1416–1424.
  11. ADA American Diabetes Association. Diabetes Care 2014 Jan;37 Suppl 1:S14-80.
  12. Levy JC, Matthews DR and Hermans MP .Correct homoestasis modelassessment (HOMA) evaluation. Diabetes Care.1998 Dec;21(12):2191-2.
  13. Martí Juanola-Falgarona, José Cándido-Fernández, J ordi Salas-Salvadó, et al ., Association between Serum Ferritin and Osteocalcin as a Potential Mechanism Explaining the Iron-Induced Insulin Resistance. PLoS One. 2013; 8(10): e76433.
  14. Chang Hee Jung, Min Jung Lee, Jenie Yoonoo Hwang et al., Elevated Serum Ferritin Level Is Associated with the Incident Type 2 Diabetes in Healthy Korean Men: A 4 Year Longitudinal Study. PLoS One. 2013;8(9): e75250.
  15. Keelan, J, Myatt, L, Mitchell, M. Endocrinology and paracrinology of parturition. in: MG Elder, LR Romero (Eds.) Preterm labour. Churchill Livingstone, London; 1997:457–491.
  16. Jiang Li, Rui Wang, Dan Luo, Shuang Li and Cheng Xiao. Association between Serum Ferritin Levels and Risk of the Metabolic Syndrome in Chinese Adults: A Population Study. PLoS One. 2013; 8(9): e74168.
  17. Jehn M, Clark JM and Guallar E .Serum ferritin and risk of the metabolic syndrome in US adults. Diabetes Care 2004; 27:2422-2428.
  18. Sarac F, Savas S, Sarac S, et al.Elevated Ferritin Levels and the Relationship with Fasting Insulin Levels in Elderly Patients with Metabolic Syndrome. Journal of Diabetes Mellitus 2014; 4(3): 242-8
  19. Hernandez C, LeCube A, Carrera A et al .Soluble transferrin receptor and ferritin in type 2 diabetes. Diabet Med 2005; 22:97-101.
  20. Kim NH, Jung Heon Oh and Kyung Mook Choi. Serum ferritin in healthy subjects and type 2 diabetic patients. Yonsei Medical Journal 2000; Vol. 41, No. 3, pp. 387-392.
  21. Sharifi F and Sazandeh SH. Serum ferritin in type 2 diabetes mellitus and its relationship with HbA1c.Acta Medica Iranica 2004 ; 42: 2.

 

 

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