Design, Synthesis of Sulfadiazine Derivatives bearing Some New Heterocyclic Compounds with study Antimicrobial and Antioxidant Activity | ||
| Egyptian Journal of Chemistry | ||
| Volume 66, Issue 2, February 2023, Pages 81-91 PDF (1.29 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2022.131305.5787 | ||
| Authors | ||
| Hala Shkyair Lihumis* ; Ameer Alameri; Rawaa Zaooli | ||
| Department of Chemistry, College of science ,University of Babylon ,Iraq | ||
| Abstract | ||
| In this work new heterocyclic derivatives were prepared. The most available (Sulfadiazine) compound treated with different aromatic aldehydes to synthesis (F1-F5) imine derivatives then cycloaddition reaction of imines with phenylthioacetic acid to produced azetidin-2-one derivatives(F6,F7). compound F1 treated ethylene glycol and hydrazine to get (F8) . (F9,F10) compounds has been synthesis by reacting (F1) compound with maleic anhydride and phthalic anhydride in dry benzene . compound F8 treated p-hydroxy benzaldehyde to get (F11) compound. Reaction (F11) with benzoyl chloride gave (F12) compound. Also, (F12) compound treated with urea to get urease derivative .These synthesized compounds (F1-F13) evaluated for their antimicrobial activity and antioxidant activity. | ||
| Keywords | ||
| Sulfadiazine; imines; azetidin-2-one; benzaldehyde; antioxidant activity | ||
|
Statistics Article View: 978 PDF Download: 607 |
||
