Alterations in Enzymes Modulating Antioxidant Balance and Oxidative Stress Indices in the Aged Rats | ||
| Journal of High Institute of Public Health | ||
| Article 5, Volume 31, Issue 1, January 2001, Pages 47-56 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jhiph.2001.238819 | ||
| Authors | ||
| Amal S.M Soliman1; Azza S. Abdou2 | ||
| 1Department of Biochemistry, Medical Research Institute, Alexandria University, Egypt | ||
| 2Department of Physiology, Medical Research Institute, Alexandria University, Egypt | ||
| Abstract | ||
| Age related changes in antioxidant enzyme levels and free radical indices were investigated in brain, heart, kidney, lung and liver tissues of adults and aged rats. Activities of superoxide dismutase [SOD] were significantly higher in all organs of aged rats except the liver. On the other hand, glutathione peroxidase [GSH-Px] activity levels were significantly higher in kidney and heart tissues only but lower in liver of old rats. However, catalase [CAT] activities were significantly lower in brains and livers and higher in lungs of the aged group. We found concomitant increases in lipid peroxides as well as oxidized glutathione in brain and liver tissues of aged rats. These data suggest that the increase of some protective enzymes could have an important role in preserving tissues from toxic effect of superoxide anion and hydrogen peroxide while decreases of other protective enzymes may be responsible for free radical damage or they may be inactivated by free radical molecules which increase with age. | ||
| Keywords | ||
| Alterations; Enzymes; Antioxidant Balance; Oxidative Stress; Aged Rats | ||
|
Statistics Article View: 81 |
||
