UNRAVELLING THE ANTIOXIDANT AND ANTI-CANCEROUS PROPERTIES OF THE CHEMICAL CONSTITUENTS PRESENT IN METHANOL EXTRACT OF GREEN ALGAE CHAETOMORPHA ANTENNINA | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Article 7, Volume 45, Issue 1, June 2022, Pages 75-87 PDF (1.07 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfsa.2022.239211 | ||
| Authors | ||
| Akanksha Dubey1; Jayanthi Sivaraman* 2 | ||
| 1Department of Biotechnology, School of Biosciences and Technology, Vellore Institute of Technology, Vellore-632 014, Tamil Nadu, India | ||
| 2Associate Professor, Computational Drug Design Lab,Department of Biotechnology,School of Biosciences and Technology,Vellore Institute of Technology, Vellore 632014,Tamil Nadu, India | ||
| Abstract | ||
| Background: Chaetomorpha antennina is a green seaweed with numerous pharmacological properties such as antimicrobial, antimalarial, anti-tumour and antioxidant properties. Thus, it is essential to perform preliminary studies to identify the chemical composition of seaweed extracts and explore the phytoconstituent responsible for pharmacological activities. Cancer is the leading cause of death worldwide. The discovery of novel therapeutic mediators for the treatment of cancer is the main task. Since efficient drug delivery is possible through nanotechnology, biosynthesis of silver nanoparticles was done, followed by molecular docking studies to investigate the anti-cancer activity of seaweed extract.Methods: Phytochemical analysis of extracts of Chaetomorpha antennina was performed, followed by biosynthesis of silver nanoparticles using these algal extracts. Characterization of silver nanoparticles was done by Scanning Electron Microscopy and X-ray Diffraction. Agar-well diffusion method and 2,2-diphenyl-1- picrylhydrazyl (DPPH) assay were used to determine the antibacterial potential and antioxidant potential of algal extracts. Further, the chemical composition of the extract was distinguished by Gas chromatography-mass spectrometry.Results: Seaweed extracts possessed numerous phytochemicals and methanol extract showed the best antibacterial and antioxidant activity. Docking studies exposed the occurrence of Carpesterol dehydrate and triazines as an anti-cancer component of Chaetomorpha antennina. Conclusion: It can be concluded that seaweed is enriched with chemical constituents possessing high antioxidant activity and therefore, can serve as a promising antioxidant and anti-cancer agent | ||
| Keywords | ||
| Antibacterial; BRCA1; Breast Cancer; Docking; GC-MS Analysis | ||
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