INFLAMMATORY STATUS IN WOMEN WITH POLYCYSTIC OVARIAN SYNDROME IN GAZA STRIP | ||
| Bulletin of Pharmaceutical Sciences Assiut University | ||
| Article 23, Volume 45, Issue 1, June 2022, Pages 289-297 PDF (659.2 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bfsa.2022.239467 | ||
| Author | ||
| Mohammed Taha* | ||
| Department of Pharmacology and Medical Sciences, Faculty of Pharmacy, Al-Azhar University of Gaza, Gaza, Palestine | ||
| Abstract | ||
| Polycystic ovary syndrome (PCOS) is a hormonal disorder that is common among women of childbearing age. The study aimed to evaluate the inflammatory status among women with PCOS in Gaza Strip by measuring C-reactive protein (CRP) concentration and white blood cell (WBC) count in women participating in the study. 180 women were selected from gynecologic private clinics in Gaza Strip were divided into three groups: healthy control group (n= 60); newly diagnosed PCOS group (n= 60); treated PCOS group (n= 60). Our results showed significant differences in the mean concentrations of FPG, FPI, FSH, and LH in the newly diagnosed PCOS patients compared with the healthy subjects as well as the treated PCOS patients. We also observed a significant increase in CRP concentrations and WBC count in the newly diagnosed PCOS patients compared with the healthy controls (p-value< 0.001, < 0.01 respectively) as well as the treated PCOS patients (p-value< 0.01, < 0.05 respectively). In conclusion, these findings suggest that PCOS can increase insulin resistance among PCOS women which may play a role in the inflammation process among PCOS women. | ||
| Keywords | ||
| Polycystic ovary syndrome; Insulin resistance; Inflammatory mediators | ||
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