Abdel-moneam, Y., Abdel-Rahim, M., Hetta, H., Herdan, O., Hassanein, K. (2022). T FOLLICULAR REGULATORY CELL (TFR) IN SYSTEMIC LUPUS ERYTHEMATOSUS AND ITS RELATION TO DISEASE ACTIVITY. test, 45(1), 401-409. doi: 10.21608/bfsa.2022.239581
Yasmien H. Abdel-moneam; Mona H. Abdel-Rahim; Helal F. Hetta; Omar M. Herdan; Khalid M. Hassanein. "T FOLLICULAR REGULATORY CELL (TFR) IN SYSTEMIC LUPUS ERYTHEMATOSUS AND ITS RELATION TO DISEASE ACTIVITY". test, 45, 1, 2022, 401-409. doi: 10.21608/bfsa.2022.239581
Abdel-moneam, Y., Abdel-Rahim, M., Hetta, H., Herdan, O., Hassanein, K. (2022). 'T FOLLICULAR REGULATORY CELL (TFR) IN SYSTEMIC LUPUS ERYTHEMATOSUS AND ITS RELATION TO DISEASE ACTIVITY', test, 45(1), pp. 401-409. doi: 10.21608/bfsa.2022.239581
Abdel-moneam, Y., Abdel-Rahim, M., Hetta, H., Herdan, O., Hassanein, K. T FOLLICULAR REGULATORY CELL (TFR) IN SYSTEMIC LUPUS ERYTHEMATOSUS AND ITS RELATION TO DISEASE ACTIVITY. test, 2022; 45(1): 401-409. doi: 10.21608/bfsa.2022.239581

T FOLLICULAR REGULATORY CELL (TFR) IN SYSTEMIC LUPUS ERYTHEMATOSUS AND ITS RELATION TO DISEASE ACTIVITY

Bulletin of Pharmaceutical Sciences Assiut University
Article 33, Volume 45, Issue 1, June 2022, Pages 401-409    PDF (634.29 K)
Document Type: Original Article
DOI: 10.21608/bfsa.2022.239581
Authors
Yasmien H. Abdel-moneam* 1; Mona H. Abdel-Rahim2; Helal F. Hetta2; Omar M. Herdan3; Khalid M. Hassanein2
1Department of Microbiology & Immunology, Faculty of Pharmacy, Assuit University, Assuit, Egypt
2Department of Microbiology & Immunology, Faculty of Medicine, Assuit University, Assuit, Egypt
3Department of Internal Medicine, Faculty of Medicine, Assuit University, Assuit, Egypt
Abstract
Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder distinguished by the presence of autoantibodies causing multiorgan damages. Follicular regulatory T (Tfr) cells are mainly located in germinal centers (GCs) and play vital role in inducing Tfh suppression, sustaining B cell tolerance and inhibiting autoantibodies development. Dysregulated Tfr cells result in abnormal GCs responses and contribute to the pathogenesis of autoimmune diseases. However, the exact role of Tfr cells in SLE is still ambiguous. The present review focuses on the immunological bases and the disturbed balance of Tfr and Tfh cells in autoimmune diseases, particularly SLE. In addition to the new therapeutic strategies for SLE.
Keywords
SLE; autoimmune diseases; innate immunity; Tfr; Tfh
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