TOXICOLOGICAL STUDIES OF MANCOZEB WITH-, AND WITHOUT WATERCRESS IN RATS. | ||
| Journal of Plant Protection and Pathology | ||
| Article 4, Volume 29, Issue 12, December 2004, Pages 7511-7522 PDF (3.53 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jppp.2004.240086 | ||
| Authors | ||
| Nahed E. Hasan,1; Samaa M. E. Bakr2; Nora F. Ghanem2 | ||
| 1Pesticides Dept., Fac. of Agric., Kafr EI-Sheikh, Tanta Univ., Egypt. | ||
| 2Biology Dept., Fac. Of Education, Kafr EI-Sheikh, Tanta Univ. Egypt. | ||
| Abstract | ||
| Some toxicological parameters of mancozeb (50 and 100 mg/kg b.w.) were studied with and without watercress on rats. Activities of some enzymes are determined in rats after treatment such as Acetylcholinesterase (AChE) in the brain, liver acid and alkaline phosphatases (ACP and ALP), glutathione-s-transferase (GST),glutamate oxaloacetate transaminase and glutamate pyruvate transaminase (GOT and GPT) and cytochrome P450 monooxygenase. Mancozeb alone reduced significantly the activities of both AChE and GST but elevated the activities of ACP and ALP, GOT, GPT and cyto. P450 monooxygenase. Mancozeb with watercress reduced AChE, phosphatases and transaminases activities significantly in the two doses than mancozeb treatment alone. On the other hand mancozeb with watercress elevated GST activity but reduced cytochrome P450 monooxygenase activities at two doses respectively. Also, mancozeb induced chromosomal aberrations in spreads of bone marrow cells of rats which consisted mainly of stickiness, fragmentation, centromeric fusion, ring, break and end to end association in two doses of mancozeb. The mitotic activity was increased at all durations in rats bone marrow cells if compared with the control. Watercress given three weeks prior to mancozeb showed inhibition of chromosomal aberrations in bone marrow cells at all intervals and also inhibition in mitotic activity when compared with animals given mancozeb only. | ||
| Keywords | ||
| Watercress; mancozeb; enzymes changes; chromosomal aberrations; . rats | ||
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