Role of Methotrexate and Thyme in Physiological Changes of Male Rat | ||
| Scientific Journal for Damietta Faculty of Science | ||
| Volume 11, Issue 2, December 2021, Pages 29-38 PDF (313.25 K) | ||
| Document Type: Original articles | ||
| DOI: 10.21608/sjdfs.2021.240753 | ||
| Authors | ||
| eman Ibrahim Khalifaa* 1; Nahed Ahmed Omar2 | ||
| 1Cell biology, histology and genetics, faculty of science, dommitta university | ||
| 2Department of Zoology, Faculty of Science, Damietta University, Egypt | ||
| Abstract | ||
| Forty adult male rats weighing (300±50) g were used and divided into 4 equal groups (10 rats/each); Group I: normal control rat group which received no treatment. Group ΙΙ: control rat administrated with thyme leave extract only at a dose (500mg/kg b.w/d) for a month, Group ΙΙΙ: rat injected intraperitoneal (i.p) with methotrexate (MTX) only at a dose (1mg/kg b.w/d) one per week for four weeks and dissolved in (2ml) of saline solution, Group ΙV: rat injected (i.p) with methotrexate at a dose (1mg/kg b.w) and administrated with thyme extract at a dose (500mg/kg b.w) daily for a month. Thyme leave extract enhanced reproductive hormones (testosterone and estradiol E2) after inhibition of MTX. MTX induced increment in MDA level but thyme improved it. Antioxidants enzymes (GR, SOD and CAT) inhibited by MTX and thyme enhanced their depression. Moreover, HB, Platelets and WBCs recorded significant decrease in group of MTX but improved in MTX and thyme treatment group. In conclusion, thyme extract is more effective in the improvement of physiological abnormalities of testicular of rat after injection with MTX. | ||
| Keywords | ||
| testis; rat; MTX; Thyme; physiological parameters | ||
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