Effect of Glyphosate on Male Fertility, Cytogenicity and Biochemical Parameters in Rats | ||
| Egyptian Journal of Chemistry and Environmental Health | ||
| Volume 4, Issue 2, November 2018, Pages 13-20 PDF (366.42 K) | ||
| Document Type: Scientific and Research | ||
| DOI: 10.21608/ejceh.2018.241065 | ||
| Authors | ||
| K. E. ElEkhnawy* 1; KM Abd-Elazzim1; Ragaa asr Faisal2; Nahla SH. kotb2 | ||
| 1Animal Health Research Institute | ||
| 2EFSA on biologicals | ||
| Abstract | ||
| Oral administration of round up in rats doses of 49 and 490 mg/kg b.wt. daily for 65 successive days respectively, significantly decreased the weight of sexual organs, sperm cell concentration and sperm motility while the sperm abnormalities were increased. The levels of creatinine, cholesterol, uric acid and bilirubin in serum were significantly increased.Round up significantly increased the activities of serum AST, ALT and AP. The tested herbicide showed mutagenic potential as measured by a positive response in the micronucleus assay. The small dose tested caused slight toxicity to the bone marrow proliferation as determined by insignificant increased rate of bone marrow cells while the large dose significantly increased the rate of bone marrow proliferation as determined by the increase the rate of ratio in tested groups over that of the control. | ||
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