Studying the Role of Irisin, Chemerin and Some Other Hormonal Levels in Obese, Diabetic (type II) and Sub-Fertile Men | ||
| Egyptian Journal of Chemistry | ||
| Volume 66, Issue 2, February 2023, Pages 183-190 PDF (834.9 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2022.135007.5939 | ||
| Authors | ||
| Raya Najim Rasool* ; Ahmed Aboud Khalifa | ||
| Department of Biology, College of Science, University of Misan, Maysan, Iraq | ||
| Abstract | ||
| Role of two polypeptides hormones Irisin and chemerin and other hormones (follicular stimulating hormone FSH, luteinizing hormone LH, testosterone T and prolactin PRL) in obese, diabetic and sub-fertile men was investigated. This investigation has 80 men aged 35-45 years, they were divided into four groups (20 men / group) as control, obesity, diabetic and sub-fertility groups. The results revealed that irisin increased significantly (p ≥ 0.01) in obesity group and decreased significantly in diabetic and sub-fertility groups in compression with the control. Chemerin increased significantly in different groups in compression with the control (p ≥ 0.01), while FSH, LH and T decreased significantly (except T in diabetic group) in different groups in comparison with the control (p ≥ 0.01). PRL increased significantly in different groups in comparison with the control (p ≥ 0.01). The physiological impact of these results were be discussed according to the influence of the fat mass (indicated by body mass index BMI), insulin resistance (IR) and the high level of prolactin hormone on all the studied parameters in obesity, diabetic and sub-fertility groups. In conclusion, the irisin and chemerin levels and their relations with the others hormones indicated a metabolic dysfunction and / or a low fertility in these different groups. | ||
| Keywords | ||
| Irisin; Chemerin; Obesity; Diabetic; Sub-fertility | ||
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