LIGHT MICROSCOPIC STUDY OF THE EFFECT OF PLATELET RICH PLASMA ON HEPATIC FIBROSIS IN ADULT MALE ALBINO RATS | ||
| ALEXMED ePosters | ||
| Article 2, Volume 5, Issue 1, January 2023, Pages 9-10 | ||
| Document Type: Preliminary preprint short reports of original research | ||
| DOI: 10.21608/alexpo.2022.142744.1416 | ||
| Authors | ||
| Ibtihag Fathy El-Ghazzawi; Amany Abdel-Moneam Solaiman; Eiman Ibrahim Zaki; Amira Ahmed Ibrahim* | ||
| Department of Histology and Cell Biology, Faculty of Medicine, Alexandria University | ||
| Abstract | ||
| Liver fibrosis is one of the most common causes of mortality worldwide. Platelet rich plasma (PRP) is one of the newly emerging modalities that contributes to tissue-healing process. Aim of the work: To study the potential effect of platelet rich plasma on hepatic fibrosis induced by thioacetamide (TAA). Material and Methods: Material: 18 adult male albino rats were randomly divided into 3 groups: Group I (control): received intraperitoneal (i.p) saline twice weekly for 7 weeks. Group II (fibrosis): received i.p injection of TAA (200 mg/kg) twice weekly for 7 weeks. Group III (treated): received i.p injection of TAA (200 mg/kg) twice weekly for 7 weeks and PRP starting from 4th week of TAA administration to the end of the experiment. Methods: • Liver fibrosis was induced by intraperitoneal injection of TAA dissolved in 0.9% normal saline in a dose of 200 mg⁄kg body weight twice a week for 7 weeks. Fifteen rats were used for the purpose of PRP preparation using double centrifugation technique. • At the end of the experiment, all groups were sacrificed and liver was taken for light microscopic examination by H&E and trichrome stains. | ||
| Keywords | ||
| fibrosis; Liver; PRP | ||
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