Izzularab, B., Beltagy, A., Meged, M., Tousson, E., Beltagy, D. (2022). Beneficial Roles of Quercetin Nanoparticles Extracted from Euphorbia Helioscopia Against Lung Damage in Mice. test, 65(131), 1487-1494. doi: 10.21608/ejchem.2022.137018.6043
Batoul Mohamed Izzularab; Amira M Beltagy; Mervet Meged; Ehab Tousson; Doha M Beltagy. "Beneficial Roles of Quercetin Nanoparticles Extracted from Euphorbia Helioscopia Against Lung Damage in Mice". test, 65, 131, 2022, 1487-1494. doi: 10.21608/ejchem.2022.137018.6043
Izzularab, B., Beltagy, A., Meged, M., Tousson, E., Beltagy, D. (2022). 'Beneficial Roles of Quercetin Nanoparticles Extracted from Euphorbia Helioscopia Against Lung Damage in Mice', test, 65(131), pp. 1487-1494. doi: 10.21608/ejchem.2022.137018.6043
Izzularab, B., Beltagy, A., Meged, M., Tousson, E., Beltagy, D. Beneficial Roles of Quercetin Nanoparticles Extracted from Euphorbia Helioscopia Against Lung Damage in Mice. test, 2022; 65(131): 1487-1494. doi: 10.21608/ejchem.2022.137018.6043

Beneficial Roles of Quercetin Nanoparticles Extracted from Euphorbia Helioscopia Against Lung Damage in Mice

Egyptian Journal of Chemistry
Volume 65, Issue 131, December 2022, Pages 1487-1494    PDF (500.34 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2022.137018.6043
Authors
Batoul Mohamed Izzularab* 1; Amira M Beltagy2; Mervet Meged3; Ehab Tousson4; Doha M Beltagy5
1Biochemistry ,Science, Damanhour University, Damanhour, Egypt
2Pharmacognosy, Pharmacy, Damanhour University, Damanhour, Egypt
3Medical Equipments , Allied Science, Pharos University, Alexandria, Egypt
4Zoology Department, Faculty of science, Tanta University, Tanta, Egypt.
5Biochemistry, Science, Damanhour University, Damanhour, Egypt
Abstract
This study aimed to evaluate the beneficial roles of quercetin nanoparticles against lung damage induced by Ehrlich ascetic's carcinoma (EAC) model in mice. Quercetin was purified from the ethanolic extract of Euphorbia helioscopia. All the confirmation chemical analysis as TLC and HPLC were performed. The conversion of quercetin to nanoparticles was carried out using poly vinyl alcohol (PVA) method. The in vivo study was carried on 90 albino mice weighed 25-30 g which were divided randomly into 6 groups; where G1 was the control group, G2 was administered with Quercetin, G3 was injected with quercetin nanoparticles, G4 is the EAC groups, G5 was injected with both EAC and quercetin, and G6 included mice injected with both EAC and quercetin nanoparticles. The lung damage and improvement prognosis were evaluated by the estimation of different oxidative stress biomarkers as reduced glutathione, malondialdehyde, superoxide dismutase, and catalase. In addition, some anti-inflammatory parameters as tumor necrosis factor-α and interleukin-6 were measured. The obtained results indicated the excellent therapeutic role of quercetin in general and the greater effect of quercetin nanoparticles in the lung tissue's improvement and recovery against the damage induced by Ehrlich model. The histological and immunohistopatholgical examinations confirmed these results.
Keywords
Quercetin; Lung damage; Malondialdehyde; Euphorbia helioscopia, interleukin-6; Quercetin nanoparticles
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