Influence of Sodium Butyrate on Provoke of Immune Response in Vaccinated Broilers With Avian Influenza (H9N2) Vaccines | ||
| Egyptian Journal of Veterinary Sciences | ||
| Article 9, Volume 53, Issue 3, August 2022, Pages 381-389 PDF (1.24 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejvs.2022.133054.1337 | ||
| Authors | ||
| Mohanad Basman Ghanim1; fanar ablahad isihak* 2 | ||
| 1Department of pathology / college of veterinary medicine / university of Mosul / Iraq | ||
| 2Department of microbiology / college of veterinary medicine / University of Mosul / Iraq | ||
| Abstract | ||
| This study aimed to evaluate the impact of sodium butyrate (SB) on immune response of broiler vaccinated with 2 different inactivated H9N2 vaccines. 150 day-old chicks were divided into 5 groups (every 30 chicks): groups A and B were vaccinated with classical inactivated avian influenza H9N2 vaccine at 1 day-old/ S.C. Group A left without treatment but group B was treated with SB with a dosage of 1g/L of drinking water daily till end of trail. Whereas groups C and D were vaccinated with a developed inactivated avian influenza H9N2P vaccine at the same age S.C. Group C was left without treatment but group D was treated with SB as group B, finally, group E was control group. The results showed no significant effect of SB on level interferon γ in treated and/or vaccinated groups. Significant effect on Abs level with SB supplementation was detected at 14 days in group D in comparison with other groups, then at 35 days SB and or developed H9N2 vaccine revealed an elevation in Abs titer in group B, C, and D respectively by ELISA and HI tests. The significant difference occurred in RW of bursa with group B in comparison with group D and E at 21 and 28 days. Finally, group B showed a significant increase in weight gain at 35 days followed by group D in comparison with other groups. We concluded that supplemented SB at 1gm/ L has a positive impact on both humoral immunity and weight gain of broiler. | ||
| Keywords | ||
| Sodium butyrate; Interferon γ; Avian influenza vaccine; Immune response | ||
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