SAFETY EVALUATION OF SOME SYNTHETIC AND NATURAL PRESERVATIVES OF COSMETIC PRODUCTS | ||
| Journal of Soil Sciences and Agricultural Engineering | ||
| Article 4, Volume 29, Issue 10, October 2004, Pages 5993-6004 PDF (3.21 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jssae.2004.243872 | ||
| Author | ||
| Nadia M. Abd- EI Moein | ||
| Department of Biochemistry, Faculty of Agriculture, Cairo University, Giza, Egypt | ||
| Abstract | ||
| The present study deals with the safety evaluation of two commonly used synthetic preservatives, i. e., germaben II (methyl-4-hydroxybenzoate) and euxyl K100 (a mixture of benzyl alcohol + methyl chloroisothiazolinone + methyl isothiazolinone) for cosmetic products. The safety of the essential oils of thyme white, thyme red and tea tree was also evaluated as susbstituents for the synthetic preservatives. Therefore, the activities of some enzymes of rat organs, i. e., alanine aminotransferase (AL T), aspartate aminotransferase (AST) , alkaline phosphatase (ALP), ribonuclease (RNase) and deoxyribonuclease (DNase) and rat serum contents, i. e., urea, total lipids, total proteins, total cholesterol, uric acid, bilirubin and creatinine were determined for rats administered both synthetic and natural preservatives under study. In addition, histopathological studies were carried out in order to emphasis the results of biochemical determination for liver and kidney functions. In general, the natural preservatives induced little changes in rat enzyme activities and serum contents. On the contrary, the synthetic preservatives caused remarkable alterations in some rat enzyme activities and serum constituents. | ||
| Keywords | ||
| Thyme oil; Tea tree oil; Germaben II; Euxyl K100; Enzyme activity; Serum constituents; Rats; Histopathological examination | ||
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