Newly Created Hybrid Nanomaterial for Treatment of Lung Carcinoma | ||
| Egyptian Journal of Chemistry | ||
| Volume 65, Issue 131, December 2022, Pages 1543-1550 PDF (525.17 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2022.134874.6127 | ||
| Authors | ||
| Aya Shaaban1; Ahmad Salem1; Faten Elramly2; Ekrami ahmed1; fatma Moawed3; Marwa Galal Eldeen Hegazy* 4 | ||
| 1Department of Biochemistry, Faculty of science, Ain Shams University, Cairo, Egypt | ||
| 2Faculty of science and humanities Prince Sattem Bin Abd Alaziz University, Hawtit Ban Tamim; Saudia Arabia | ||
| 3Health radiation research, National Center for Radiation Research and Technology, Atomic Energy Authority, Cairo, Egypt | ||
| 4Biochemistry, faculty of Science, Ain Shams university | ||
| Abstract | ||
| Deficient passage of therapeutic cargo into tumor bed is a bottleneck in cancer nanomedicine. Interest has been manifested in use of chitosan-based nanoparticles with utilizing metal oxide hybrid nanocomposite in nanomedicine. We synthesis, characterize, and investigate a hybrid nanomaterial (CHNM) anti-cancer activity. A developed CHNM of magnesium oxide nanoparticles coupled with cisplatin and coated with chitosan biopolymer were characterized by FTIR, X-ray diffraction, TEM and SEM. Anti-cancer effects were evaluated in A549 cell line. CHNM nanoparticles showed a diameter of ∼240 nm with a negatively charged surface (−25.4 ± 3.75 mV) and mean particle size of 24.2 ± 7.89 nm. CHNM showed a high encapsulation efficiency (78%), drug loading efficiency (80%) and maximum cisplatin release (2- 6 h). CHNM showed improved anti-cancer activity on A549 cells (IC50=50.8 µg/ml). In conclusion, magnesium oxide nanoparticles coupled with cisplatin and coated with chitosan biopolymer could be used as promising lung cancer treatment system. | ||
| Keywords | ||
| Lung cancer; Cisplatin; hybrid nanomaterial; Chemotherapy | ||
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