The Prophylactic Effect of Royal Jelly in Amelioration of 6-Mercaptopurine - Induced Testicular Damage in Albino Rats (Histological and Immunohistochemical study) | ||
| Journal of Medical Histology | ||
| Article 4, Volume 5, Issue 1, June 2021, Pages 48-59 PDF (2.13 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jmh.2022.125328.1096 | ||
| Author | ||
| Samraa Abdel-Kawi* | ||
| Department of Medical Histology and Cell Biology, Faculty of Medicine, Beni-Suef University, Egypt. | ||
| Abstract | ||
| Background: Testicular toxicity is a well-documented adverse impact of a large number of chemotherapeutic drugs. 6-mercaptopurine (6MP) is an anti-cancer agent with strong anti-tumor activity. Despite this, it has a detrimental impact on the male reproductive system. Royal jelly (RJ) is a nutrient-dense substance that may also include antibacterial, antioxidant, and anti-inflammatory characteristics. These qualities may account for the majority of royal jelly's health claims. This study aimed to investigate the protective effect of RJ on 6MP-induced testicular damage in adult albino rats. Materials and Methods: Forty male adult albino rats were categorized into four equivalent groups (n= 10): control, RJ group < br />(200 mg/kg RJ for 30 days), 6MP group (5 mg/kg 6MP for 20 days), and RJ+6MP group (200 mg/kg RJ for 10 days alone then concomitant with 5 mg/kg 6MP for 20 days). Histological and immunohistochemical examinations of the testes were performed. Results: The histological results revealed that oral administration of 6MP triggers a substantial reduction in testis weights, count, sperm motility %, and viability. 6MP also caused severe testicular degeneration with weak immunoreactivity to Bcl- 2and N-Cadherin. RJ attenuated testicular degeneration and upregulated the expression of Bcl-2 and N-Cadherin. Conclusion: RJ reduced all testicular changes induced by 6MP. Thus, RJ may be a viable medication for infertility problems associated with testicular injuries. | ||
| Keywords | ||
| 6MP; Bcl-2; N-Cadherin; Royal Jelly; testis | ||
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