Evaluation of Obstructive Sleep Apnea in Metabolic Syndrome | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 182, Volume 88, Issue 1, July 2022, Pages 3417-3422 PDF (804.09 K) | ||
| DOI: 10.21608/ejhm.2022.248719 | ||
| Authors | ||
| Medhat Fahmy Negm1; Mohammad Hussein Kamel1; Walaa Mohammad Ebrahim2; Zeinab Gaber Nor-Eldein* 1; Shaimaa Magdy AboYoussef1 | ||
| 1Departments of 1Chest Disease | ||
| 22Internal Medicine, Faculty of Medicine, Benha University, Egypt | ||
| Abstract | ||
| Background: There is bidirectional relationship between obstructive sleep apnea and metabolic disease. Sleep apnea results in intermittent hypoxia and sleep fragmentation, which lead to and exacerbate obesity and type 2 diabetes by increasing sympathetic activity, oxidative stress, inflammation and lipolysis. Moreover, metabolic disease can lead to or exacerbate sleep apnea through weight-dependent and physiology-dependent mechanisms. Objective: The studyaimed toexplore the association between metabolic syndrome and obstructive sleep apnea (OSA). Patients and Methods: This study was conducted at Sleep Unit of Chest Department Benha University Hospitals. This study enrolled 100 patients that were divided into two groups: Group A, which included 80 patients with metabolic syndrome as cases and group B that included 20 patients without metabolic syndrome as control group. All patients included in this study were subjected to lipid profile, HbA1c, overnight polysomnography (PSG). Results: There was highly statistically significant positive correlation between apnea hypopnea index (AHI) and waist circumference, TG, HbA1C, systolic blood pressure, diastolic blood pressure and sum all night desaturation. There was highly statistically significant negative correlation between AHI and HDL and minimal SPO2. TG, HDL, Hb A1C and systolic and diastolic blood pressure were significant predictors for increase AHI and increase OSA severity. Conclusion: OSA was highly prevalent in patients with metabolic syndrome, which is associated with increasing severity of OSA. Also, it is associated with poorer control of diabetes, hypertension, and dyslipidemia, which are all components of metabolic syndrome. | ||
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