Impact of Hyaluronic acid on healing of tongue ulcers in diabetic rats | ||
| Egyptian Dental Journal | ||
| Article 18, Volume 68, Issue 3, July 2022, Pages 2409-2418 PDF (2.68 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/edj.2022.137075.2099 | ||
| Authors | ||
| Amira Moawad* 1; Sally Abobaker2 | ||
| 1Department of Oral Biology, Faculty of Dentistry, Mansoura University Department of Maxillofacial Surgery and Diagnostic Science, Faculty of Dentistry, Majmaah University. Saudi Arabia. | ||
| 2Department of Oral Biology, Faculty of Dentistry, Mansoura University Department of Basic Dental& Medical sciences, Faculty of Dentistry, Ha’il University. | ||
| Abstract | ||
| Introduction: Wound healing is a highly complicated process achieved through definitely programmed stages. Hyaluronic acid is a natural component present essentially in the skin and other connective tissues, it has been used in many medical fields for acceleration of wound healing. Aim: This study aimed to investigate the therapeutic effect of hyaluronic acid on healing of tongue ulcer in diabetic rat model. Material & Methods: Thirty male Albino rats were subjected to diabetes induction and after 1 week the animals were classified into 3 groups, Group I: rats were subjected to tongue ulcer and did not receive any treatment. Group II: rats were subjected to tongue ulcer and the ulcers were treated with 3 times/ day topical applications of commercially used 0.2% high molecular weight hyaluronic acid. Group III: rats were received 1-2 IU/ g/day of insulin NPH injected subcutaneous and then subjected to tongue ulcer after one week from the starting of insulin injection. The animals were sacrificed at 4 and 10 days after ulcer induction, specimens were prepared for histological examination and immunohistochemical staining for α-SMA. Results: Histological examination revealed better enhancement of ulcer healing and re-epithelization together with reorganization of the epithelium and connective tissue in group II and III samples when compared to group I after 4 and 10 days of ulcer induction. Conclusion: oral application of hyaluronic acid gel has beneficial effects in accelerating wound healing and improving all phases of wound repair in tongue ulcers in rats. | ||
| Keywords | ||
| tongue ulcer; hyaluronic acid; insulin; α-SMA | ||
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