Toxicity study of methanol extract of Rosa damascena trigintipetala in mice | ||
| Egyptian Journal of Chemistry | ||
| Volume 66, Issue 4, April 2023, Pages 253-264 PDF (3.18 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2022.146123.6358 | ||
| Authors | ||
| Abdel-Nasser Sabra1; Salih Bazaid2; El sayed Saleh* 3 | ||
| 1Pharmacology Department, Theodor Bilharz Research Institute, Kornish El-Nile-Warrak El-Hadar, Imbaba, Giza 12411, Egypt. | ||
| 2College of Sciences, Taif University, P. O. Box 11099, Taif 21944, Saudi Arabia | ||
| 3Medicinal Chemistry Lab., Theodor Bilharz Research Institute, Giza, Egypt | ||
| Abstract | ||
| Rose is one of the most important ornamental plants, with economic and cultural importance. In this work, the methanol extract of Taif rose (Rosa damascena trigintipetala Dieck) was investigated for its toxicity (Acute, Sub-chronic and Chronic) and long-term side effects. Also, the effect of dose accumulation on physiological parameters and histopathological changes in normal mice was studied. The results of this study showed that no toxicity indication of methanol extract of Taif rose during acute, sub-chronic and chronic periods on physiological parameters while the pathological studies showed minimal changes in the vital organs. From this work, it is clear that Taif rose methanol extract could be utilised as a good natural, affordable, and safe therapy. | ||
| Keywords | ||
| Taif Rose; methanol extract; acute; sub-chronic; chronic toxicity; mice | ||
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