Acrylamide-Induced Ovarian Toxicity in Female Wistar Albino Rats | ||
| Sohag Journal of Sciences | ||
| Volume 7, Issue 3, September 2022, Pages 111-115 PDF (651.8 K) | ||
| Document Type: Regular Articles | ||
| DOI: 10.21608/sjsci.2022.147919.1006 | ||
| Author | ||
| Nagwa Mohamed El sawi* | ||
| Department of Chemistry, Faculty of Science, Sohag University, Sohag, 82524, Egypt. | ||
| Abstract | ||
| Acrylamide was well known to induce reproductive toxicity with an impact on reproductive functions on both male and female. The current investigation was designed as a trial to assess any changes in ovarian hormones and histology brought on by the administration of acrylamide for three weeks. Methods: Animals were split into two groups (N = 10) and fed a healthy diet. and DMSO (1%) saline (9%), Acrylamide (AA) group received acrylamide in saline (9%), (20 mg/kg b. w.) for 21days. Alteration in the level of ovarian hormones were assayed and correlated with histological changes in ovarian tissue. Results: Estradiol levels in the serum were considerably increased after acrylamide administration, but progesterone levels were significantly decreased. Histological study revealed that AA causes cyst formation, corpus luteum d generation which pointed to ovarian follicular regression. In conclusion: Results showed that AA modulated hormonal levels in female rats that related to alteration in ovarian structure | ||
| Keywords | ||
| Keywords: Acrylamide; Oxidative stress; Ovarian Toxicity; Histological study | ||
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