Histopathological and Scores Assessment of Using Omega-3 for Improvement Gingival Wound Healing Process in Rabbit Model | ||
| Egyptian Journal of Veterinary Sciences | ||
| Volume 53, Issue 4, December 2022, Pages 517-527 PDF (2.48 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejvs.2022.147321.1358 | ||
| Authors | ||
| Omar Mahmoud1; Jawnaa Mammdoh2; Mohammed Ghassan Saeed* 3 | ||
| 1Department of Dental Basic Sciences, College of Dentistry, University of Mosul, Mosul, Iraq | ||
| 2Department of Basic sciences, College of Dentistry, University of Mosul, Mosul, Iraq | ||
| 3Department of Pathology and Poultry Diseases, College of Veterinary Medicine, University of Mosul, Mosul, Iraq | ||
| Abstract | ||
| The aim of this trail is to using omega-3 as a prophylactic or curative, or both on gingival injury healing in rabbits. To attain this objective has been employed 36 rabbits, were divided into 3 groups, each with 12 animals. The first group were considered as a control group, receiving normal saline for 10 days, while the second group received omega-3 for 10 days before gingival incision. The third group received omega-3 for 10 days before and continuous treatment for 10 days after the gingival incision. An incision was done in the gingival (0.5 cm) in all groups. The group given Omega-3 for 10 days before and after the woundperforming had the superior results of the preceding therapies. It enhanced re-epithelization score and substantial increase in granulation tissue formation and angiogenesis, and decreaseinflammation scores. The histopathological section (3 days post-surgery) showed the site of the wound with re-epithelialization (score 4), granulation tissue (score 2), angiogenesis (score 3), and without inflammation (score 0), as well as 7 days post-surgery were the same scores except the score of granulation tissuewas 3. Using omega-3 has a superior effect, especially when used for both prophylactic and treatment, and it helped to reduce inflammatory markers while improving healing indications such as re-epithelialization, granulation tissue, and angiogenesis. As a result, omega-3 can be considered a beneficial value as antimicrobial agent in the treatment of wounds and gingivitis. | ||
| Keywords | ||
| Omega-3; Gingival wound; Inflammation; Histopathological changes | ||
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