Biocompatibility Assessment of Chamomile Volatile Oil, Double Antibiotic Paste in Subcutaneous Tissue of Rats | ||
| Egyptian Journal of Chemistry | ||
| Volume 65, Issue 132, December 2022, Pages 1355-1368 PDF (1.37 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2022.151522.6566 | ||
| Authors | ||
| Maha Mamdouh Elsaid* 1; Elsayed A. Omer2; Wael Hussien Kamel3; Abeer Ali Salama4; Heba AbdelKafy1 | ||
| 1Department of Endodontics, Al-Azhar University, Faculty of Dental Medicine for Girls, Cairo, Egypt | ||
| 2Medicinal and Aromatic Plants Research Department, National Research Centre, 33 El-Bohouth St., P.O. 12622, Dokki, Giza, Egypt. | ||
| 3Endodontic Department, Faculty of Dental Medicine for Girl's Al-Azhar University, Cairo, Egypt. | ||
| 4pharmacology, NRC | ||
| Abstract | ||
| This study aimed to assess the biocompatibility of Matricaria Recutita volatile oil versus 1% double antibiotic paste on subcutaneous tissue in rats through implantation testing. Thirty-six rats were selected for In Vivo assay. The prepared polyethylene tubes were sealed at one end with cyanoacrylate gel carrying the tested medicament and divided into 3 groups (I, II, and III) (36 tubes each) representing the tested material. Group I is the control group (Empty tube), group II comprises 1% DAP (5µl), whereas group III comprises Chamomile volatile oil (2.5µl) according to effective antimicrobial concentration against E. faecalis (ATCC29212), each group was subdivided according to the post-implantation evaluation period at 7, 14, and 21 days. Animals were euthanized and tissue sections were prepared for histopathological and microscopic assessments of inflammation and fibrous capsule thickness & length of each group at different time intervals. The values of fibrous capsule thickness & length (µm) were of the highest value in 1% DAP associated with the highest inflammation intensity followed by the control group, while the lowest value of fibrous capsule thickness & length was in the chamomile group associated with less inflammation, respectively at all-time intervals with statistically significant difference between them. Therefore, chamomile volatile oil exhibits superior biocompatibility over 1% DAP with promising application in endodontics as a biocompatible intracanal disinfectant. | ||
| Keywords | ||
| Biocompatibility; Chamomile volatile oil; Double antibiotic paste; Implantation test | ||
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