TERATOGENIC EFFECTS OF CARBOSULFAN IN FEMALE ALBINO RATS | ||
| Journal of Plant Protection and Pathology | ||
| Article 1, Volume 27, Issue 6, June 2002, Pages 4131-4143 PDF (3.63 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jppp.2002.253745 | ||
| Authors | ||
| R M. Sherif1; K. A. Gouhar1; M. M. Farid2; A. A. Gharib2 | ||
| 1Plant Protection Dept., Fac. of Agric., Zagazig Univ. | ||
| 2Central Agric. Pesticides lab. (CAPl), Agric. Res. Center, Dokki, Giza. | ||
| Abstract | ||
| Teratogenic effects of carbosulfan in albino female rats (Rattus rattus) during organogenesis period (from the 6th to 15th day of gestation) was investigated. Three doses 18.5,9.25 and 4.63 mglkg b.wt. corresponding to 1/10,1/20,1/40 of the LD50' respectively, were used. The morphological changes revealed that, the alive foetus per dam was decreased with selected doses, while the percent post-implantation death, percent of implantation loss and the number of dead foetuses per dam were increased at the tested doses. Also, the mean foetal weights, the mean foetal crown-ramp, length and the mean weight of placenta were reduced markedly. However, visceral examination of viable foetuses showed dilated renal pelvis, distended urinary bladder with urine, cleft palate, dilation of lateral ventricles and cerebral, hemispheres (a symmetric). The' mostcommon skeletal malformations were wavy and shorting ribs, reduce o'r absence of sternbrae and absence of digits of fore- and hind-limbs, and some coccygeal vertebrae. Also, cranial bone absent (skull incomplete ossificationj-was observed. | ||
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