THE EFFECT OF T-DEPENDENT ANTIGEN ON THE PROFILES OF CIRCULATING WHITE BLOOD CELLS, CORTICOSTERONE, T3, T4 AND GLUCOSE DURING THE INITIATION OF HUMORAL IMMUNE RESPONSE IN WHITE LEG HORNE COCKERELS. | ||
| Journal of Animal and Poultry Production | ||
| Article 6, Volume 27, Issue 7, July 2002, Pages 4483-4494 PDF (1.29 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jappmu.2002.255876 | ||
| Author | ||
| A. M. Atta, | ||
| Department of Animal Production, Faculty of Agriculture, Cairo University. | ||
| Abstract | ||
| This study was conducted to monitor the early physiological events during the initiation of the humoral immune response. This would eventually benefit the development of superior poultry immunization program. One hundred and twenty male white Leghorn cockerels aged eight-week-old were injected intravenously with either 0.5 ml of 10% sheep red blood cells (SRBC), a T-dependent antigen, or saline. Blood samples were collected at O. 1, 3, 6. 9 and 24h foll9wing the injection. Total white blood cells (WBC), differential counts, corticosterone, T3, T. and glucose concentrations were measured in all blood samples. Total WBC counts. lymphocytes (L) and monocytes decreased significantly at 3. 6 and 9h post SRBC injection. However, Circulating heterophils (H) and HIL ratio increased significantly at 1, 3. 6 and 9h post SRBC injection. Serum corticosterone and glucose concentrations increased significantly at 3h and 6h and at 3 h post SRBC injection respectively. On the other hand, serum T3 and T4 decreased significantly at 3h post SRBC injection. There were no significant changes in total WBC count, lymphocytes and heterophils count, serum corticosterone and glucose levels following saline injection. However, monocytes decreased significantly at 6h and 9h. T. decreased significantly at 3h. while T3 increased at 1h post saline injection as compared to Oh. These results showed that injection of the T-dependent antigen, SRBC, initiates a wide variety of hormonal, immune logical and metabolic changes in the chickens. These changes may explain the Interaction between the neuroendocrine and immune system. | ||
| Keywords | ||
| hicken; immune response. white blood cells; corticosteron. T3. T •. glucose | ||
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